{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:23:34Z","timestamp":1788621814601,"version":"build-2803163510"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2024,6,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>Parechovirus A (PeV-A) infections have been detected with increasing frequency in US infants under 6 months of age, leading to a Centers for Disease Control and Prevention (CDC) health advisory in July 2022. Clinicians are advised to consider PeV-A laboratory testing of blood and cerebrospinal fluid when infants present with unexplained fever, sepsis-like illness, or neurological issues. Clinical laboratories are encouraged to offer in-house molecular testing for PeV-A to avoid diagnostic delays, unnecessary use of antibiotics, and prolonged hospitalization of infants presenting with sepsis-like illness. While data are evolving on potential neurodevelopmental sequelae after PeV-A infant central nervous system infections, most infected infants return to baseline health for age. This review examines the PeV-A literature with a focus on PeV-A3, including aspects of epidemiology, clinical presentations\/management, laboratory diagnostics, genotyping, and post-infectious sequelae related to PeV-A infections in infants.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/jcm.01139-23","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T13:00:24Z","timestamp":1713790824000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Diagnosis, management, and outcomes of parechovirus infections in infants: an overview"],"prefix":"10.1128","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7559-1796","authenticated-orcid":true,"given":"Anjana","family":"Sasidharan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children\u2019s Mercy Hospital and Clinics, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Harrison","sequence":"additional","affiliation":[{"name":"University of Missouri, College of Medicine, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-6657","authenticated-orcid":true,"given":"Rangaraj","family":"Selvarangan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children\u2019s Mercy Hospital and Clinics, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22023"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6434a3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6718a2"},{"key":"e_1_3_1_5_2","first-page":"1577","article-title":"Nonpolio enterovirus and human parechovirus surveillance --- United States, 2006-2008","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","unstructured":"Centers for Disease Control and Prevention. 2010. 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