{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:54:30Z","timestamp":1792637670895,"version":"4.5.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Capsular serotypes,\n            <jats:italic>magA<\/jats:italic>\n            , and\n            <jats:italic>rmpA<\/jats:italic>\n            have been documented in high prevalence for\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            liver abscess. To investigate the regional difference and the correlation of capsular serotype,\n            <jats:italic>magA<\/jats:italic>\n            , and\n            <jats:italic>rmpA<\/jats:italic>\n            with virulence, 73 isolates were collected in Singapore and Taiwan. Capsular serotypes were determined by countercurrent immunoelectrophoresis, the presence of\n            <jats:italic>magA<\/jats:italic>\n            and\n            <jats:italic>rmpA<\/jats:italic>\n            was determined by PCR, and virulence was determined by phagocytosis and mouse inoculation. Isolates from Singapore were similar to those from Taiwan in genomic heterogeneity, prevalence of serotype, and the presence of\n            <jats:italic>magA<\/jats:italic>\n            and\n            <jats:italic>rmpA.<\/jats:italic>\n            The most common serotype was K1 (34\/73; 46.6%), followed by K2 (15\/73; 20.5%).\n            <jats:italic>magA<\/jats:italic>\n            was restricted to serotype K1. All K1 or K2 isolates and 66.7% (16\/24) of isolates that were neither serotype K1 nor serotype K2 (non-K1\/K2) carried\n            <jats:italic>rmpA<\/jats:italic>\n            . Serotype K1 or K2 isolates demonstrated significantly more phagocytic resistance and virulence than did\n            <jats:italic>rmpA<\/jats:italic>\n            -positive and -negative groups of non-K1\/K2 isolates. In the non-K1\/K2 group, the virulence profiles of\n            <jats:italic>rmpA<\/jats:italic>\n            -positive strains from Taiwan and Singapore were different by phagocytosis assay and in the mouse model, indicating that factors other than\n            <jats:italic>rmpA<\/jats:italic>\n            contributed to virulence. The characteristics of\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            liver abscess in Singapore and Taiwan are similar. Capsular serotype K1 or K2 plays a more important role than\n            <jats:italic>magA<\/jats:italic>\n            and\n            <jats:italic>rmpA<\/jats:italic>\n            in determining virulence in\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            liver abscess.\n          <\/jats:p>","DOI":"10.1128\/jcm.01150-06","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T02:10:56Z","timestamp":1165457456000},"page":"466-471","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":266,"title":["Capsular Serotype K1 or K2, Rather than\n            <i>magA<\/i>\n            and\n            <i>rmpA<\/i>\n            , Is a Major Virulence Determinant for\n            <i>Klebsiella pneumoniae<\/i>\n            Liver Abscess in Singapore and Taiwan"],"prefix":"10.1128","volume":"45","author":[{"given":"Kuo-Ming","family":"Yeh","sequence":"first","affiliation":[{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center"},{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kurup","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. K.","family":"Siu","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Division of Clinical Research, National Health Research Institutes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. L.","family":"Koh","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Phone","family":"Fung","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Chung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yee","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse-Hsien","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Singapore General Hospital, 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