{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:51:55Z","timestamp":1787899915010,"version":"build-2784847793"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Previously, a small study showed that 14f was the predominant subtype of\n            <jats:named-content content-type=\"genus-species\">Treponema pallidum<\/jats:named-content>\n            in Shanghai, China. The result was quite different from the genotype distribution in other areas of China. This study aimed to identify the strain types of\n            <jats:named-content content-type=\"genus-species\">Treponema pallidum<\/jats:named-content>\n            in samples collected over a 5-year period in Shanghai. From 2007 to 2011, genital swabs were collected from patients with syphilis from the Shanghai Skin Disease Hospital. Positive specimens were typed by the enhanced typing method by adding a\n            <jats:italic>tp0548<\/jats:italic>\n            gene to the existing\n            <jats:italic>arp<\/jats:italic>\n            and\n            <jats:italic>tpr<\/jats:italic>\n            genotype system. In total, 304 of the 372 enrolled patients yielded fully typeable DNA. Ten\n            <jats:italic>arp<\/jats:italic>\n            types (4, 6, 8, 9, 11, 12, 13, 14, 15, and 19), 3\n            <jats:italic>tpr<\/jats:italic>\n            types (a, d, and o), and 5\n            <jats:italic>tp0548<\/jats:italic>\n            types (a, c, f, g, and i) were identified. In total, 12 subtypes were identified with a combination of the\n            <jats:italic>arp<\/jats:italic>\n            and\n            <jats:italic>tpr<\/jats:italic>\n            genes. Subtype 14d was found in 270 samples (88.8%). When the combination included the\n            <jats:italic>tp0548<\/jats:italic>\n            gene, the 12 CDC subtypes identified were divided into 14 strain types. The predominant type was 14d\/f (88.8%), followed by 15d\/f (3.6%), 13d\/f (1.3%), and 19d\/c (1.3%). Two of the 44 14d\/f-infected patients and both of the 19d\/c-infected patients who underwent a lumbar puncture were diagnosed with neurosyphilis. This study showed that the predominant type in Shanghai was 14d\/f. While this is in keeping with data from other areas in China, it is different from an earlier report showing that 14f is the most common genotype in Shanghai. Further studies are needed to better understand the association between strain types and neurosyphilis.\n          <\/jats:p>","DOI":"10.1128\/jcm.01195-12","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T02:32:10Z","timestamp":1347503530000},"page":"3674-3677","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Molecular Typing of Treponema pallidum: a 5-Year Surveillance in Shanghai, China"],"prefix":"10.1128","volume":"50","author":[{"given":"Ting","family":"Dai","sequence":"first","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of STD Institute, Shanghai Skin Disease Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of STD Institute, Shanghai Skin Disease Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of STD Institute, Shanghai Skin Disease Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of STD Institute, Shanghai Skin Disease Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00287-08"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60074-9"},{"key":"e_1_3_2_4_2","first-page":"9","article-title":"2011 report on syphilis and gonorrhea epidemic analysis in China","volume":"26","author":"Chinese Center for Disease Prevention and Control; Center for, STI, and AIDS Prevention and Control","year":"2012","unstructured":"Chinese Center for Disease Prevention and Control; Center for, STI, and AIDS Prevention and Control. 2012. 2011 report on syphilis and gonorrhea epidemic analysis in China. 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