{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:17:12Z","timestamp":1788923832003,"version":"build-2803163510"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"HHS | NIH | National Center for Advancing Translational Sciences","award":["UL1 TR002377"],"award-info":[{"award-number":["UL1 TR002377"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              A total of 1,925\n              <jats:italic>Corynebacterium<\/jats:italic>\n              isolates were tested for antimicrobial susceptibility at the Mayo Clinic Microbiology laboratory (Rochester, Minnesota) from January 2012 to March 2023, with\n              <jats:italic>C. striatum<\/jats:italic>\n              (35.6%) and\n              <jats:italic>C. amycolatum<\/jats:italic>\n              (24.4%) identified as the predominant species. Species known to potentially carry diphtheria toxin were excluded. Common sources of isolation included skin and soft tissue (56.8%), bone and\/or native joint synovial fluid (14.2%), urine (13.1%), sputum (6.1%), and blood (5.9%). For penicillin, susceptibility decreased from 47.5% (58 of 122) in 2012 to 20.6% (14 of 68) in 2023. Isolates also showed a decrease in susceptibility to erythromycin from 22.4% (26 of 116) in 2012 to 13.2% (9 of 68) in 2023. Susceptibility to trimethoprim-sulfamethoxazole averaged around 50% throughout the period. Notably, linezolid and vancomycin were universally effective\n              <jats:italic>in vitro<\/jats:italic>\n              against all species. The highest susceptibility rates among tested oral agents were to linezolid and doxycycline for non-\n              <jats:italic>C<\/jats:italic>\n              .\n              <jats:italic>striatum<\/jats:italic>\n              species. Daptomycin minimal inhibitory concentrations (MICs) of &gt;256 \u00b5g\/mL were observed for one\n              <jats:italic>C. amycolatum<\/jats:italic>\n              isolate, one\n              <jats:italic>C. tuberculostearicum<\/jats:italic>\n              isolate, and for seven\n              <jats:italic>C. striatum<\/jats:italic>\n              isolates, all from patients with prior daptomycin exposure. Daptomycin MICs of 2 \u00b5g\/mL (nonsusceptible) were observed in one\n              <jats:italic>C. striatum<\/jats:italic>\n              isolate recovered from a daptomycin-na\u00efve patient and in six\n              <jats:italic>C. jeikeium<\/jats:italic>\n              isolates, from both daptomycin-exposed and non-exposed patients. Significant variation in susceptibility profiles across different\n              <jats:italic>Corynebacterium<\/jats:italic>\n              species underscores the importance of performing antimicrobial susceptibility testing to guide effective treatment. Moreover, multidrug resistance observed in\n              <jats:italic>C. striatum<\/jats:italic>\n              poses substantial therapeutic challenges especially in patients requiring prolonged or chronic antibiotic suppression.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/jcm.01199-24","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T14:00:11Z","timestamp":1731938411000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Retrospective analysis of antimicrobial susceptibility profiles of non-\n            <i>diphtheriae Corynebacterium<\/i>\n            species from a tertiary hospital and reference laboratory, 2012\u20132023"],"prefix":"10.1128","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-6700","authenticated-orcid":false,"given":"Ryan B.","family":"Khodadadi","sequence":"first","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-5259","authenticated-orcid":false,"given":"Said","family":"El Zein","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-3264","authenticated-orcid":false,"given":"Christina G.","family":"Rivera (O'Connor)","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan W.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-270X","authenticated-orcid":false,"given":"Audrey N.","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M.","family":"Abu Saleh","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3630-0668","authenticated-orcid":false,"given":"Madiha","family":"Fida","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00796-12"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/528713"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00457-09"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12883"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1805-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2211.160141"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9010031"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01776-17"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinmicnews.2015.11.003"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.208"},{"key":"e_1_3_4_12_2","volume-title":"CLSI guideline M45","author":"CLSI","year":"2016","unstructured":"CLSI. 2016. 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