{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:59:59Z","timestamp":1767164399319,"version":"build-2238731810"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    New Caledonia is an archipelago in the South Pacific with a high prevalence of acute rheumatic fever and rheumatic heart disease. Conducted in 2006, this study aimed at characterizing clinical manifestations and microbial features of isolates obtained from invasive\n                    <jats:italic>Streptococcus pyogenes<\/jats:italic>\n                    disease. Clinical and demographic data were collected prospectively. Isolates were biotyped, T typed,\n                    <jats:italic>emm<\/jats:italic>\n                    sequenced, and tested for antibiotic susceptibility. Detection of the\n                    <jats:italic>speA<\/jats:italic>\n                    ,\n                    <jats:italic>speB<\/jats:italic>\n                    ,\n                    <jats:italic>speC<\/jats:italic>\n                    , and\n                    <jats:italic>ssa<\/jats:italic>\n                    genes was also carried out. The estimated annual incidence of invasive\n                    <jats:italic>S. pyogenes<\/jats:italic>\n                    disease in 2006 was high at 38 cases\/100,000 inhabitants in New Caledonia. Invasive isolates were obtained from 90 patients with necrotizing fasciitis (41 cases), bacteremia with no identified focus (12 cases), myositis (10 cases), septic arthritis (9 cases), erysipelas (8 cases), postpartum infection (4 cases), myelitis and osteomyelitis (3 cases), severe pneumonia (2 cases), and endocarditis (1 case). The most frequent associated comorbidities were skin lesions (71%) and obesity (29%). Thirty-one different\n                    <jats:italic>emm<\/jats:italic>\n                    types were identified, and the following six accounted for 54% of the isolates:\n                    <jats:italic>emm<\/jats:italic>\n                    15 (15.5%),\n                    <jats:italic>emm<\/jats:italic>\n                    92 (12.2%),\n                    <jats:italic>emm<\/jats:italic>\n                    106 (8.9%),\n                    <jats:italic>emm<\/jats:italic>\n                    74 (6.7%),\n                    <jats:italic>emm<\/jats:italic>\n                    89 (5.6%), and\n                    <jats:italic>emm<\/jats:italic>\n                    109 (5.6%). The\n                    <jats:italic>speA<\/jats:italic>\n                    ,\n                    <jats:italic>speC<\/jats:italic>\n                    , and\n                    <jats:italic>ssa<\/jats:italic>\n                    genes were expressed at different frequencies in the various\n                    <jats:italic>emm<\/jats:italic>\n                    types. The first epidemiological study of invasive\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>pyogenes<\/jats:italic>\n                    disease in New Caledonia highlights that\n                    <jats:italic>emm<\/jats:italic>\n                    type distribution is particular and should be taken into account in the development of an appropriate vaccine. These findings support the prevention of pyoderma and other cutaneous lesions in order to limit the development of both invasive disease and poststreptococcal sequelae in the South Pacific.\n                  <\/jats:p>","DOI":"10.1128\/jcm.01205-09","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T22:10:27Z","timestamp":1259791827000},"page":"526-530","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Clinical and Microbial Characteristics of Invasive\n                    <i>Streptococcus pyogenes<\/i>\n                    Disease in New Caledonia, a Region in Oceania with a High Incidence of Acute Rheumatic Fever"],"prefix":"10.1128","volume":"48","author":[{"given":"S.","family":"Le Hello","sequence":"first","affiliation":[{"name":"Molecular Epidemiology Laboratory, Institut Pasteur de Nouvelle-Cale\u0301donie, Noume\u0301a, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Doloy","sequence":"additional","affiliation":[{"name":"National Center for Streptococci, Paris Descartes University, Ho\u0302tel Dieu, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Laboratory, Institut Pasteur de Nouvelle-Cale\u0301donie, Noume\u0301a, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Roques","sequence":"additional","affiliation":[{"name":"Internal Me\u0301decine Department, G. Bourret, Noume\u0301a, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Coudene","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Laboratory, Institut Pasteur de Nouvelle-Cale\u0301donie, Noume\u0301a, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rouchon","sequence":"additional","affiliation":[{"name":"Department and Agency of Health and Social Affairs of New Caledonia, Noume\u0301a, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lacassin","sequence":"additional","affiliation":[{"name":"Internal Me\u0301decine Department, G. Bourret, Noume\u0301a, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bouvet","sequence":"additional","affiliation":[{"name":"National Center for Streptococci, Paris Descartes University, Ho\u0302tel Dieu, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1410.071660"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.4.953-958.1996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040275"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/315842"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.5.1312-1317.1994"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70267-X"},{"key":"e_1_3_2_8_2","unstructured":"Streptococcus pyogenes emm sequence database. 2006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3523-3534.2000"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.470"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31818128ce"},{"key":"e_1_3_2_12_2","first-page":"37","year":"1996","unstructured":"Johnson, D. 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