{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:49:53Z","timestamp":1761630593367},"reference-count":33,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To explore alternative cervical cancer screening approaches in an underserved population, we compared the performance of human papillomavirus (HPV) DNA assays in combination with different sample collection methods for primary cervical screening in the Mississippi Delta region. Three specimens were collected from women aged 26 to 65 years who were either routinely undergoing screening (\n            <jats:italic>n<\/jats:italic>\n            = 252) or not (\n            <jats:italic>n<\/jats:italic>\n            = 191): clinician-collected cervical specimens, clinician-collected cervicovaginal specimens, and self-collected cervicovaginal specimens taken at home. A novel collection device and medium were used for cervicovaginal sampling. Specimens were tested by three HPV DNA assays: hybrid capture 2 (HC2; Qiagen Corp., Gaithersburg, MD), Linear Array (LA; Roche Molecular Systems, Pleasanton, CA), and Amplicor (Roche Molecular Systems, Pleasanton, CA). Liquid-based cytology was performed on cervical specimens. We compared the overall positivity (a proxy for clinical specificity) for any carcinogenic HPV genotype and calculated the agreement across assay and specimen type using McNemar's test for differences in test positivity. Across all three assays there were no significant differences between clinician-collected and self-collected cervicovaginal specimens (\n            <jats:italic>P<\/jats:italic>\n            &gt; 0.01 for all comparisons). For both cervicovaginal specimens (clinician collected and self-collected), fewer women tested positive by HC2 than by LA or Amplicor (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01 for all comparisons). HC2 had the best agreement between specimens for all assays. HC2 is likely more clinically specific, although possibly less sensitive, than either PCR test. Thus, use of HC2 on cervicovaginal specimens for screening could result in fewer referrals compared to LA and Amplicor.\n          <\/jats:p>","DOI":"10.1128\/jcm.01254-11","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T05:30:44Z","timestamp":1318483844000},"page":"4185-4189","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Comparative Performance of Human Papillomavirus DNA Testing Using Novel Sample Collection Methods"],"prefix":"10.1128","volume":"49","author":[{"given":"Julia C.","family":"Gage","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward E.","family":"Partridge","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfio","family":"Rausa","sequence":"additional","affiliation":[{"name":"Mississippi State Department of Health, Jackson, Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patti E.","family":"Gravitt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sholom","family":"Wacholder","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Scarinci","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E.","family":"Castle","sequence":"additional","affiliation":[{"name":"American Society for Clinical Pathology, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9474-0"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20506"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25144"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000159549.56601.75"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61450-0"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2011.03.018"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0909"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00824-08"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-7-200804010-00004"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9596-4"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/152460902753668466"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000266396.25244.68"},{"key":"e_1_3_1_14_2","volume-title":"NIH pub. no. 05-5282","author":"Freeman H. P.","year":"2005","unstructured":"FreemanH. P. WingroveB. K.. 2005. Excess cervical cancer mortality: a marker for low access to health care in poor communities. NIH pub. no. 05-5282. National Cancer Institute, Center to Reduce Cancer Health Disparities, Rockville, MD."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606040"},{"key":"e_1_3_1_16_2","first-page":"517","article-title":"Experience with high-risk human papillomavirus testing on vaginal brush-based self-samples of non-attendees of the cervical screening program","volume":"129","author":"Gok M.","year":"2011","unstructured":"GokM.. 2011. Experience with high-risk human papillomavirus testing on vaginal brush-based self-samples of non-attendees of the cervical screening program. Int. J. Cancer 129:517\u2013527.","journal-title":"Int. J. 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Preliminary evaluation of a cervical self-sampling device with liquid-based cytology and multiparameter molecular testing. J. Reprod. Med. 50:256\u2013260.","journal-title":"J. Reprod. Med."},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-10-200005160-00009"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073204"},{"key":"e_1_3_1_24_2","first-page":"36","article-title":"And what words shall describe the Mississippi, great father of rivers?","volume":"36","author":"Parfit M","year":"1993","unstructured":"ParfitM. 1993. And what words shall describe the Mississippi, great father of rivers? Smithsonian 36:36.","journal-title":"Smithsonian"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.01.023"},{"key":"e_1_3_1_26_2","unstructured":"Qiagen. 2004. Hybrid Capture 2 High-Risk HPV DNA test package insert. 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