{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:24:08Z","timestamp":1791239048375,"version":"4.1.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cryptococcosis is primarily caused by\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            and\n            <jats:italic>Cryptococcus gattii.<\/jats:italic>\n            These two pathogenic species each divide into four distinct molecular genotypes. In this study, we examined whether genotype influenced susceptibility to antifungal drugs used to treat cryptococcosis using the broth microdilution method described by the Clinical and Laboratory Standards Institute.\n            <jats:italic>C. gattii<\/jats:italic>\n            isolates belonging to molecular genotype VGII had significantly higher MIC values for flucytosine and all azole antifungal agents tested, particularly fluconazole, than isolates of other\n            <jats:italic>C. gattii<\/jats:italic>\n            genotypes. In an extended analysis of fluconazole susceptibility, VGII isolates from the north and west of Australia required higher drug levels for inhibition than those from Vancouver Island, Canada. Within\n            <jats:italic>C. neoformans<\/jats:italic>\n            , genotype VNII had significantly lower geometric mean MICs for fluconazole than genotype VNI. These results indicate that cryptococcal species, molecular genotype, and region of origin may be important when deciding treatment options for cryptococcosis.\n          <\/jats:p>","DOI":"10.1128\/jcm.01271-10","type":"journal-article","created":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T02:28:03Z","timestamp":1284604083000},"page":"4115-4120","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["<i>In Vitro<\/i>\n            Susceptibility of the Yeast Pathogen\n            <i>Cryptococcus<\/i>\n            to Fluconazole and Other Azoles Varies with Molecular Genotype"],"prefix":"10.1128","volume":"48","author":[{"given":"Hin Siong","family":"Chong","sequence":"first","affiliation":[{"name":"School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Dagg","sequence":"additional","affiliation":[{"name":"School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malik","sequence":"additional","affiliation":[{"name":"Centre for Veterinary Education, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, Westmead Hospital, and University of Sydney, Westmead, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee","family":"Carter","sequence":"additional","affiliation":[{"name":"School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1544-1548.2000"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2134\/jeq2003.1258"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(08)70019-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2007.12.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/597306"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000850"},{"key":"e_1_3_2_8_2","first-page":"62","volume":"1","year":"2009","unstructured":"Byrnes, E. 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