{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:04:26Z","timestamp":1791227066302,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Mycobacterium marinum<\/jats:named-content>\n            causes a systemic tuberculosis-like disease in fish and skin infections in humans that can spread to deeper structures, resulting in tenosynovitis, arthritis, and osteomyelitis. However, little information is available concerning (i) the intraspecific genetic diversity of\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            isolated from humans and animals; (ii)\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            genotype circulation in the different ecosystems, and (iii) the link between\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            genetic diversity and hosts (humans and fish). Here, we conducted a genetic study on 89\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            isolates from humans (\n            <jats:italic>n<\/jats:italic>\n            = 68) and fish (\n            <jats:italic>n<\/jats:italic>\n            = 21) by using mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) typing. The results show that the\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            population is genetically structured not only according to the host but also according to the ecosystem as well as to tissue tropism in humans. This suggests the existence of different genetic pools in the function of the biological and ecological compartments. Moreover, the presence of only certain\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            genotypes in humans suggests a different zoonotic potential of the\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            genotypes. Considering that the infection is linked to aquarium activity, a significant genetic difference was also detected when the human tissue tropism of\n            <jats:named-content content-type=\"genus-species\">M. marinum<\/jats:named-content>\n            was taken into consideration, with a higher genetic polymorphism in strains isolated from patients with cutaneous forms than from individuals with deeper-structure infection. It appears that only few genotypes can produce deeper infections in humans, suggesting that the immune system might play a filtering role.\n          <\/jats:p>","DOI":"10.1128\/jcm.01274-12","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T05:11:49Z","timestamp":1346908309000},"page":"3627-3634","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Genetic Diversity and Population Structure of Mycobacterium marinum: New Insights into Host and Environmental Specificities"],"prefix":"10.1128","volume":"50","author":[{"given":"Vincent","family":"Broutin","sequence":"first","affiliation":[{"name":"INSERM U1058 Infection by HIV and by agents with mucocutaneous tropism: from pathogenesis to prevention, Montpellier, France"},{"name":"Centre Hospitalier R\u00e9gional Universitaire de Montpellier, H\u00f4pital Arnaud de Villeneuve, D\u00e9partement de Bact\u00e9riologie-Virologie, Montpellier, France"},{"name":"MIVEGEC, UMR IRD 224-CNRS 5290-Universit\u00e9s Montpellier 1 et 2, Centre IRD, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Ba\u00f1uls","sequence":"additional","affiliation":[{"name":"MIVEGEC, UMR IRD 224-CNRS 5290-Universit\u00e9s Montpellier 1 et 2, Centre IRD, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Aubry","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Mycobact\u00e9ries et de la R\u00e9sistance aux Antituberculeux, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Keck","sequence":"additional","affiliation":[{"name":"Laboratoire D\u00e9partemental V\u00e9t\u00e9rinaire de l'H\u00e9rault, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Choisy","sequence":"additional","affiliation":[{"name":"MIVEGEC, UMR IRD 224-CNRS 5290-Universit\u00e9s Montpellier 1 et 2, Centre IRD, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Bernardet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de virologie et immunologie mol\u00e9culaires, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Michel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de virologie et immunologie mol\u00e9culaires, Institut National de la Recherche Agronomique, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Raymond","sequence":"additional","affiliation":[{"name":"Comit\u00e9 National des P\u00eaches Maritimes et des Elevages Marins, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Libert","sequence":"additional","affiliation":[{"name":"Parc zoologique Darwin, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Barnaud","sequence":"additional","affiliation":[{"name":"Le Gouessant Aquaculture, Lamballe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Stragier","sequence":"additional","affiliation":[{"name":"Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Portaels","sequence":"additional","affiliation":[{"name":"Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Terru","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional Universitaire de Montpellier, H\u00f4pital Arnaud de Villeneuve, D\u00e9partement de Bact\u00e9riologie-Virologie, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Belon","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional Universitaire de Montpellier, H\u00f4pital Arnaud de Villeneuve, D\u00e9partement de Bact\u00e9riologie-Virologie, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dereure","sequence":"additional","affiliation":[{"name":"INSERM U1058 Infection by HIV and by agents with mucocutaneous tropism: from pathogenesis to prevention, Montpellier, France"},{"name":"Department of Dermatology, H\u00f4pital Saint-Eloi, University of Montpellier"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"FIND, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Laura","family":"Boschiroli","sequence":"additional","affiliation":[{"name":"ANSES, Laboratoire de Sant\u00e9 Animale de Maisons-Alfort, Unit\u00e9 des Zoonoses Bact\u00e9riennes, Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Van De Perre","sequence":"additional","affiliation":[{"name":"INSERM U1058 Infection by HIV and by agents with mucocutaneous tropism: from pathogenesis to prevention, Montpellier, France"},{"name":"Centre Hospitalier R\u00e9gional Universitaire de Montpellier, H\u00f4pital Arnaud de Villeneuve, D\u00e9partement de Bact\u00e9riologie-Virologie, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Cambau","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Mycobact\u00e9ries et de la R\u00e9sistance aux Antituberculeux, Paris, 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