{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:54:15Z","timestamp":1791986055401,"version":"4.4.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Between 2008 and 2011, population-based candidemia surveillance was conducted in Atlanta, GA, and Baltimore, MD. Surveillance had been previously performed in Atlanta in 1992 to 1993 and in Baltimore in 1998 to 2000, making this the first population-based candidemia surveillance conducted over multiple time points in the United States. From 2,675 identified cases of candidemia in the current surveillance, 2,329\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            isolates were collected.\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            no longer comprised the majority of isolates but remained the most frequently isolated species (38%), followed by\n            <jats:named-content content-type=\"genus-species\">Candida glabrata<\/jats:named-content>\n            (29%),\n            <jats:named-content content-type=\"genus-species\">Candida parapsilosis<\/jats:named-content>\n            (17%), and\n            <jats:named-content content-type=\"genus-species\">Candida tropicalis<\/jats:named-content>\n            (10%). The species distribution has changed over time; in both Atlanta and Baltimore the proportion of\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            isolates decreased, and the proportion of\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            isolates increased, while the proportion of\n            <jats:named-content content-type=\"genus-species\">C. parapsilosis<\/jats:named-content>\n            isolates increased in Baltimore only. There were 98 multispecies episodes, with\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            the most frequently encountered combination. The new species-specific CLSI\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            MIC breakpoints were applied to these data. With the exception of\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            (11.9% resistant), resistance to fluconazole was very low (2.3% of isolates for\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            , 6.2% for\n            <jats:named-content content-type=\"genus-species\">C. tropicalis<\/jats:named-content>\n            , and 4.1% for\n            <jats:named-content content-type=\"genus-species\">C. parapsilosis<\/jats:named-content>\n            ). There was no change in the proportion of fluconazole resistance between surveillance periods. Overall echinocandin resistance was low (1% of isolates) but was higher for\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            isolates, ranging from 2.1% isolates resistant to caspofungin in Baltimore to 3.1% isolates resistant to anidulafungin in Atlanta. Given the increase at both sites and the higher echinocandin resistance,\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            should be closely monitored in future surveillance.\n          <\/jats:p>","DOI":"10.1128\/jcm.01283-12","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T06:04:01Z","timestamp":1344492241000},"page":"3435-3442","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":268,"title":["Species Identification and Antifungal Susceptibility Testing of Candida Bloodstream Isolates from Population-Based Surveillance Studies in Two U.S. Cities from 2008 to 2011"],"prefix":"10.1128","volume":"50","author":[{"given":"Shawn R.","family":"Lockhart","sequence":"first","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naureen","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela A.","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Farley","sequence":"additional","affiliation":[{"name":"Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA"},{"name":"Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee H.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol B.","family":"Bolden","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Baughman","sequence":"additional","affiliation":[{"name":"Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Stein","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Hollick","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Park","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Chiller","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/513663"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01811-10"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.9.3489-3492.2002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90349-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1210.060389"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh548"},{"key":"e_1_3_2_8_2","unstructured":"Clinical and Laboratory Standards Institute\n. \n2008. \nReference method for broth dilution antifungal susceptibility testing of yeasts. 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