{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:42:30Z","timestamp":1789875750559,"version":"4.0.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Trichomoniasis is a common sexually transmitted disease associated with preterm birth, low birth weight, and increased susceptibility to infection with other pathogenic sexually transmitted microorganisms. Nucleic acid amplification tests for\n            <jats:named-content content-type=\"genus-species\">Trichomonas vaginalis<\/jats:named-content>\n            have improved sensitivity for detecting infected individuals compared to existing culture-based methods. This prospective, multicenter U.S. clinical trial evaluated the performance of the automated Aptima\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            assay for detecting\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            in 1,025 asymptomatic and symptomatic women. Vaginal swab, endocervical swab, ThinPrep PreservCyt, and urine specimens were collected. Subject infection status was determined by wet-mount microscopy and culture. Aptima\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            assay performance was determined for each specimen type by comparison to subject infection status. Of 933 subjects analyzed, 59.9% were symptomatic. Aptima\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            clinical sensitivity and specificity were, respectively, 100% and 99.0% for vaginal swabs, 100% and 99.4% for endocervical swabs, 100% and 99.6% in ThinPrep samples, and 95.2% and 98.9% in urine specimens. Aptima\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            performance levels were similar in asymptomatic and symptomatic subjects. This study validates the clinical performance of the Aptima\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            assay for screening asymptomatic and symptomatic women for\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            infection.\n          <\/jats:p>","DOI":"10.1128\/jcm.01291-11","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T05:47:01Z","timestamp":1316670421000},"page":"4106-4111","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":127,"title":["Molecular Testing for Trichomonas vaginalis in Women: Results from a Prospective U.S. Clinical Trial"],"prefix":"10.1128","volume":"49","author":[{"given":"Jane R.","family":"Schwebke","sequence":"first","affiliation":[{"name":"Departments of Medicine\/Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia M.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie N.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Section of Infectious Diseases, Louisiana State University Health Sciences Center, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene C.","family":"Sena","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Catania","sequence":"additional","affiliation":[{"name":"Research and Development, Gen-Probe Inc., San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Weinbaum","sequence":"additional","affiliation":[{"name":"Research and Development, Gen-Probe Inc., San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Research and Development, Gen-Probe Inc., San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon K.","family":"Getman","sequence":"additional","affiliation":[{"name":"Research and Development, Gen-Probe Inc., San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Gaydos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200605000-00049"},{"key":"e_1_3_2_3_2","author":"BioMed Diagnostics","year":"2007","unstructured":"BioMed Diagnostics. 2007. InPouch TV Trichomonas vaginalis test. BioMed Diagnostics, White City, OR.","journal-title":"InPouch TV Trichomonas vaginalis test"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.1.148-152.1994"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00671-08"},{"issue":"11","key":"e_1_3_2_6_2","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2006","volume":"55","author":"Centers for Disease Control and Prevention","year":"2006","unstructured":"Centers for Disease Control and Prevention. 2006. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm. Rep. 55(RR-11):1\u201394.","journal-title":"MMWR Recomm. Rep."},{"key":"e_1_3_2_7_2","unstructured":"Centers for Disease Control and Prevention. 2007. CDC fact sheet: trichomoniasis. http:\/\/www.cdc.gov\/std\/trichomonas\/STDFact-Trichomoniasis.htm. Accessed 12 September 2010."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.6.4.519"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70682-8"},{"key":"e_1_3_2_10_2","unstructured":"Gen-Probe Inc. 2010. APTIMA Trichomonas vaginalis assay for in vitro diagnostic use. Gen-Probe Inc. San Diego CA. http:\/\/www.gen-probe.com\/pdfs\/pi\/502246-EN-RevB.pdf."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5619-5622.2003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01447-06"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.2.684-687.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/518851"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199301000-00015"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.10.3585-3588.2000"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.12.3308-3310.1997"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00564-08"},{"key":"e_1_3_2_20_2","first-page":"66","article-title":"Trichomonas vaginalis transcription-mediated amplification-based analyte-specific reagent and alternative target testing of primary clinical vaginal saline suspensions. Diagn. Microbiol","volume":"68","author":"Munson E.","year":"2010","unstructured":"MunsonE.. 2010. Trichomonas vaginalis transcription-mediated amplification-based analyte-specific reagent and alternative target testing of primary clinical vaginal saline suspensions. Diagn. Microbiol. Infect. Dis. 68:66\u201372.","journal-title":"Infect. 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