{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:58:29Z","timestamp":1764687509369},"reference-count":10,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Reactivation of latent varicella-zoster virus (VZV), presenting as localized zoster or as disseminated infection, is a common and potentially serious complication in hematopoietic stem cell transplantation (HSCT) recipients. We retrospectively studied anti-VZV immunoglobulin G titers by the immune adherence hemagglutination method after HSCT and also studied VZV DNA by real-time PCR during clinical VZV reactivation using cryopreserved serum samples. No significant difference was found between anti-VZV titers in 13 patients with VZV infection (localized zoster in 11 patients and disseminated zoster in 2 patients) and in 13 subjects without VZV infection at each time point after HSCT. Preexisting anti-VZV titers of disseminated zoster cases tended to be lower than those of localized zoster cases (\n            <jats:italic>P<\/jats:italic>\n            = 0.10). Serum VZV DNA copy numbers at the onset of disseminated zoster cases tended to be higher than those of localized zoster cases (\n            <jats:italic>P<\/jats:italic>\n            = 0.09). A strong inverse correlation was found between preexisting anti-VZV titer and serum VZV DNA at onset (\n            <jats:italic>r<\/jats:italic>\n            = \u22120.90,\n            <jats:italic>P<\/jats:italic>\n            = 0.006). In HSCT recipients, preexisting antibody does not prevent the development of VZV reactivation but may contribute to decreased viral load at onset, resulting in a mild clinical course.\n          <\/jats:p>","DOI":"10.1128\/jcm.01312-06","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T18:54:05Z","timestamp":1165431245000},"page":"4441-4443","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Relationship between Preexisting Anti-Varicella-Zoster Virus (VZV) Antibody and Clinical VZV Reactivation in Hematopoietic Stem Cell Transplantation Recipients"],"prefix":"10.1128","volume":"44","author":[{"given":"Masahiro","family":"Onozawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hashino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsumi","family":"Takahata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumie","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Kahata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(00)70004-8"},{"key":"e_1_3_2_3_2","first-page":"2731","year":"2001","unstructured":"Arvin, A. M. 2001. Varicella-zoster virus, p. 2731-2767. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott-Raven Publishers, Philadelphia, Pa.","journal-title":"Fields virology"},{"key":"e_1_3_2_4_2","first-page":"RR","volume":"49","year":"2004","unstructured":"Centers for Disease Control and Prevention. 2004. CDC guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Morbid. Mortal. Wkly. Rep.49:RR-10.","journal-title":"Morbid. Mortal. Wkly. Rep."},{"key":"e_1_3_2_5_2","first-page":"277","volume":"13","year":"1994","unstructured":"Han, C. S., W. Miller, R. Haake, and D. Weisdorf. 1994. Varicella-zoster infection after bone marrow transplantation: incidence, risk factors and complications. Bone Marrow Transplant.13:277-283.","journal-title":"Bone Marrow Transplant."},{"key":"e_1_3_2_6_2","first-page":"1010","volume":"135","year":"1997","unstructured":"Kalter, Z. G., S. Steinberg, and A. A. Gershon. 1997. Immune adherence hemagglutination: further observations on demonstration of antibody to varicella-zoster virus. J. Infect. Dis.135:1010-1013.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702119"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1979.03630490011007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.4.2.199"},{"key":"e_1_3_2_10_2","first-page":"191","volume":"4","year":"1989","unstructured":"Wacker, P., O. Hartmann, E. Benhamou, E. Salloum, and J. lemerle. 1989. Varicella-zoster virus infections after autologous bone marrow transplantation in children. Bone Marrow Transplant.4:191-194.","journal-title":"Bone Marrow Transplant."},{"key":"e_1_3_2_11_2","first-page":"737","volume":"149","year":"1983","unstructured":"Zaia, J. A., M. J. Levin, S. R. Preblud, et al. 1983. Evaluation of varicella-zoster immune globulin: protection of immunosuppressed children after household exposure to varicella. J. Infect. Dis.149:737-743.","journal-title":"J. Infect. Dis."}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01312-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01312-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T04:23:44Z","timestamp":1646454224000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01312-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1128\/JCM.01312-06"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01312-06","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"2006-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}