{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:26:05Z","timestamp":1771017965485,"version":"3.50.1"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Joint Biology Consortium","award":["P30 AR070253"],"award-info":[{"award-number":["P30 AR070253"]}]},{"DOI":"10.13039\/100013479","name":"Bay Area Lyme Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001645","name":"Boehringer Ingelheim Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014731","name":"Global Lyme Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:p>Lyme disease is commonly diagnosed by serologic response to<jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>and related species, but the relationship between serologic targets and clinical features is unknown. We developed a multiantigen Luminex-based panel and evaluated IgG responses in 527 children 1 to 21\u2009years of age assessed for Lyme disease across 4 Pedi Lyme Net emergency departments, including 127 Lyme cases defined by either an erythema migrans (EM) lesion or positive C6 enzyme immunoassay followed by immunoblotting and 400 patients considered clinical mimics.<\/jats:p>","DOI":"10.1128\/jcm.01344-21","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T18:54:59Z","timestamp":1628708099000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Serologic Response to<i>Borrelia<\/i>Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease"],"prefix":"10.1128","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6491-2573","authenticated-orcid":true,"given":"Felix A.","family":"Radtke","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitya","family":"Ramadoss","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris","family":"Garro","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA"},{"name":"Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan E.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, A.I. Dupont Hospital for Children, Wilmington, Delaware, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Levas","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Children\u2019s Hospital of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA"},{"name":"VA Palo Alto Health Care System, Palo Alto, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Division of Immunology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-3997","authenticated-orcid":true,"given":"Lise E.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Lyme borreliosis.","author":"Steere AC","year":"2018","unstructured":"Steere AC, Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. 2018. Lyme borreliosis. McGraw-Hill Education, New York, NY."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6622a1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-725"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix943"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02111-15"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01785-19"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08151"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01142-19"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.10.012"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60665-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2612.200920"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3275"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1314325"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.04.004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00122-07"},{"key":"e_1_3_3_17_2","unstructured":"Dattwyler RJ Gomes-Solecki MJC. 15 February 2011. Peptide diagnostic agent for Lyme disease. US patent US7887815B2."},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","DOI":"10.1002\/9781394260638","volume-title":"Explaining psychological statistics","author":"Cohen BH","year":"2013","unstructured":"Cohen BH. 2013. Explaining psychological statistics, 4th ed. Wiley, New York, NY.","edition":"4"},{"key":"e_1_3_3_19_2","first-page":"231","volume-title":"The handbook of research synthesis.","author":"Rosenthal R","year":"1994","unstructured":"Rosenthal R. 1994. Parametric measures of effect size, p 231\u2013244. In The handbook of research synthesis. Russell Sage Foundation, New York, NY."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v028.i05"},{"key":"e_1_3_3_21_2","volume-title":"R: a language and environment for statistical computing.","author":"R Core Team.","year":"2020","unstructured":"R Core Team. 2020. R: a language and environment for statistical computing. R Core Development Team, Vienna, Austria."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_3_3_24_2","unstructured":"Kassambara A. 2020. ggpubr: 'ggplot2' based publication ready plots. R package version 0.4.0. https:\/\/CRAN.R-project.org\/package=ggpubr."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v025.i01"},{"key":"e_1_3_3_26_2","unstructured":"Kassambara A Mundt F. 2020. factoextra: extract and visualize the results of multivariate data analyses. R package version 1.0.7. https:\/\/CRAN.R-project.org\/package=factoextra."},{"key":"e_1_3_3_27_2","unstructured":"Wei T Simko V. 2021. R package 'corrplot': visualization of a correlation matrix version 0.90. https:\/\/github.com\/taiyun\/corrplot."},{"key":"e_1_3_3_28_2","unstructured":"Weiner J. 2020. pca3d: three dimensional PCA plots. R package version 0.10.2. https:\/\/CRAN.R-project.org\/package=pca3d."},{"key":"e_1_3_3_29_2","unstructured":"Kassambara A. 2021. rstatix: pipe-friendly framework for basic statistical tests. R package version 0.7.0. https:\/\/CRAN.R-project.org\/package=rstatix."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.12.6702-6706.1999"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00276.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008516"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01950-05"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.11.3036-3044.1995"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1273"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1215"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000028"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01344-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01344-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:26:16Z","timestamp":1725611176000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01344-21"}},"subtitle":[],"editor":[{"given":"Elitza S.","family":"Theel","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,10,19]]}},"alternative-id":["10.1128\/JCM.01344-21"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01344-21","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]},"assertion":[{"value":"2021-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01344-21"}}