{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:31:46Z","timestamp":1789475506007,"version":"build-2803163510"},"reference-count":76,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            subsp.\n            <jats:italic>paratuberculosis<\/jats:italic>\n            causes Johne's disease, a systemic infection and chronic inflammation of the intestine that affects many species, including primates. Infection is widespread in livestock, and human populations are exposed. Johne's disease is associated with immune dysregulation, with involvement of the enteric nervous system overlapping with features of irritable bowel syndrome in humans. The present study was designed to look for an association between\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            subsp.\n            <jats:italic>paratuberculosis<\/jats:italic>\n            infection and irritable bowel syndrome. Mucosal biopsy specimens from the ileum and the ascending and descending colon were obtained from patients with irritable bowel syndrome attending the University of Sassari, Sassari, Sardinia, Italy. Crohn's disease and healthy control groups were also included.\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            subsp.\n            <jats:italic>paratuberculosis<\/jats:italic>\n            was detected by IS\n            <jats:italic>900<\/jats:italic>\n            PCR with amplicon sequencing. Data on the potential risk factors for human exposure to these pathogens and on isolates from Sardinian dairy sheep were also obtained.\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            subsp.\n            <jats:italic>paratuberculosis<\/jats:italic>\n            was detected in 15 of 20 (75%) patients with irritable bowel syndrome, 3 of 20 (15%) healthy controls, and 20 of 23 (87%) people with Crohn's disease (\n            <jats:italic>P<\/jats:italic>\n            = 0.0003 for irritable bowel syndrome patients versus healthy controls and\n            <jats:italic>P<\/jats:italic>\n            = 0.0000 for Crohn's disease patients versus healthy controls). One subject in each group had a conserved single-nucleotide polymorphism at position 247 of IS\n            <jats:italic>900<\/jats:italic>\n            that was also found in isolates from seven of eight dairy sheep. There was a significant association (\n            <jats:italic>P<\/jats:italic>\n            = 0.0018) between\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            subsp.\n            <jats:italic>paratuberculosis<\/jats:italic>\n            infection and the consumption of hand-made cheese.\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            subsp.\n            <jats:italic>paratuberculosis<\/jats:italic>\n            is a candidate pathogen in the causation of a proportion of cases of irritable bowel syndrome as well as in Crohn's disease.\n          <\/jats:p>","DOI":"10.1128\/jcm.01371-07","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T00:53:46Z","timestamp":1191459226000},"page":"3883-3890","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":101,"title":["<i>Mycobacterium avium<\/i>\n            Subspecies\n            <i>paratuberculosis<\/i>\n            Infection in Cases of Irritable Bowel Syndrome and Comparison with Crohn's Disease and Johne's Disease: Common Neural and Immune Pathogenicities"],"prefix":"10.1128","volume":"45","author":[{"given":"Antonio M.","family":"Scanu","sequence":"first","affiliation":[{"name":"Instituto di Clinica Chirurgica Generale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Bull","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences-Surgery, St. George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cannas","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo A.","family":"Sechi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Dettori","sequence":"additional","affiliation":[{"name":"Instituto di Clinica Chirurgica Generale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Zanetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hermon-Taylor","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences-Surgery, St. George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-43.2.302"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.031"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00875.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.039"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.6.767"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098587801500206"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.2915-2923.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-8508(03)00047-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.7223-7227.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10169"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.020"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.58.030603.123726"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.01.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80001-1"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.02.009"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1409-1422.2004"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.024"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00726-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-68.5.966"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70211-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.025"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00102.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90832-J"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.002"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5345-5348.2004"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.3.387"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01004-06"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0468"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-6-10"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.1974-1982.2004"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100512"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800704"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058879"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.046"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007737"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20059"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.20506\/rst.20.1.1275"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68265-2"},{"key":"e_1_3_2_41_2","first-page":"21","volume":"24","year":"2006","unstructured":"Maxion-Bergemann, S., F. Thielecke, F. Abel, and R. Bergemann. 2006. Costs of irritable bowel syndrome in the UK and US. Pharmacoeconomics24:21-37.","journal-title":"Pharmacoeconomics"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.5.1011"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.08.075"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.1.854-859.2006"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05834.x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17058-X"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.11.009"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.118646"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.10.014"},{"key":"e_1_3_2_50_2","first-page":"407","volume":"15","year":"2005","unstructured":"Oshitani, N., K. Watanabe, S. Nakamura, Y. Fujiwara, K. Higuchi, and T. Arakawa. 2005. Dislocation of tight junction proteins without F-actin disruption in inactive Crohn's disease. Int. J. Mol. Med.15:407-410.","journal-title":"Int. J. Mol. Med."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.10.010"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.04143.x"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.4.2130-2139.2005"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02490-05"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64789-X"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200502000-00004"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00687.x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.051"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00265.x"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41415.x"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.1081-1083.2006"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2006.12.005"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.307"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70551-2"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.041426"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.10.1760"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1925-8"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000225338.14356.d5"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023657"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37059"},{"key":"e_1_3_2_71_2","first-page":"133","volume":"66","year":"2003","unstructured":"Tuncer, C., M. Cindoruk, A. Dursun, and T. Karakan. 2003. Prevalence of microscopic colitis in patients with symptoms suggesting irritable bowel syndrome. Acta Gastroenterol. Belg.66:133-136.","journal-title":"Acta Gastroenterol. Belg."},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000158536.31557.90"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000219350.72483.44"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.721"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.1002-1008.2001"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-2-127"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059026"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01371-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01371-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T05:32:59Z","timestamp":1646458379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01371-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":76,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1128\/JCM.01371-07"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01371-07","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"2007-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}