{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:51:46Z","timestamp":1792461106934,"version":"4.5.0"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Community-associated methicillin-resistant\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            (CA-MRSA) is a prevalent cause of skin and soft tissue infections (SSTI), but the association between CA-MRSA colonization and infection remains uncertain. We studied the carriage frequency at several body sites and the diversity of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            strains from patients with and without SSTI. Specimens from the nares, throat, rectum, and groin of case subjects with a closed skin abscess (i.e., without drainage) and matched control subjects without a skin infection (\n            <jats:italic>n<\/jats:italic>\n            = 147 each) presenting to 10 U.S. emergency departments were cultured using broth enrichment; wound specimens were cultured from abscess cases. Methicillin resistance testing and\n            <jats:italic>spa<\/jats:italic>\n            typing were performed for all\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            isolates.\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            was found in 85\/147 (57.8%) of abscesses; 49 isolates were MRSA, and 36 were methicillin-susceptible\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            (MSSA). MRSA colonization was more common among cases (59\/147; 40.1%) than among controls (27\/147; 18.4%) overall (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) and at each body site; no differences were observed for MSSA.\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            -infected subjects were usually (75\/85) colonized with the infecting strain; among MRSA-infected subjects, this was most common in the groin. The CC8 lineage accounted for most of both infecting and colonizing isolates, although more than 16 distinct strains were identified. Nearly all MRSA infections were inferred to be USA300. There was more diversity among colonizing than infecting isolates and among those isolated from controls versus cases. CC8\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            is a common colonizer of persons with and without skin infections. Detection of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            colonization, and especially MRSA, may be enhanced by extranasal site culture.\n          <\/jats:p>","DOI":"10.1128\/jcm.01371-15","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T22:33:11Z","timestamp":1441233191000},"page":"3478-3484","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":62,"title":["Staphylococcus aureus Colonization and Strain Type at Various Body Sites among Patients with a Closed Abscess and Uninfected Controls at U.S. Emergency Departments"],"prefix":"10.1128","volume":"53","author":[{"given":"Valerie S.","family":"Albrecht","sequence":"first","affiliation":[{"name":"Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi M.","family":"Limbago","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Olive View-UCLA Medical Center, Sylmar, California, USA"},{"name":"Division of Infectious Diseases, Olive View-UCLA Medical Center, Sylmar, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Krishnadasan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Olive View-UCLA Medical Center, Sylmar, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Gorwitz","sequence":"additional","affiliation":[{"name":"Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda K.","family":"McDougal","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Talan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Olive View-UCLA Medical Center, Sylmar, California, USA"},{"name":"Division of Infectious Diseases, Olive View-UCLA Medical Center, Sylmar, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"919","article-title":"Methicillin-resistant Staphylococcus aureus skin or soft tissue infections in a state prison\u2014Mississippi, 2000","volume":"50","author":"Centers for Disease Control and Prevention","year":"2001","unstructured":"Centers for Disease Control and Prevention. 2001. Methicillin-resistant Staphylococcus aureus skin or soft tissue infections in a state prison\u2014Mississippi, 2000. MMWR Morb Mortal Wkly Rep 50:919\u2013922.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir308"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.3.505"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/422997"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90063-U"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042859"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/533494"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02121-06"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701302501"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02836.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05323-11"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(98)70071-X"},{"key":"e_1_3_2_14_2","volume-title":"Document M02-A11","author":"CLSI","year":"2012","unstructured":"CLSI. 2012. Performance standards for antimicrobial disk susceptibility tests; approved standard, 11th ed. Document M02-A11. 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