{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:46:48Z","timestamp":1792003608560,"version":"4.4.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Lactobacillus<\/jats:named-content>\n spp. are associated with the maintenance of reproductive health, but obesity reduces fertility and is a risk factor for obstetric and neonatal complications. We assessed the association between obesity and the cervical\n Lactobacillus<\/jats:named-content>\n composition, which has not been examined previously. Pyrosequencing was performed using cervical swabs collected from 76 normal participants with negative results for cervical intraepithelial neoplasia (CIN) and 57 participants with CIN, based on histological examinations. Cluster analysis of nine\n Lactobacillus<\/jats:named-content>\n spp. was performed, and five cluster types were identified. The association between obesity and the\n Lactobacillus<\/jats:named-content>\n community was assessed by logistic regression analysis after adjustment for confounding factors. The proportion of\n Lactobacillus iners<\/jats:named-content>\n increased and that of\n Lactobacillus crispatus<\/jats:named-content>\n decreased according to body mass index (BMI) categories, i.e., underweight (BMI of <18.5 kg m\n \u22122<\/jats:sup>\n ), normal weight (BMI of 18.5 to 22.9 kg m\n \u22122<\/jats:sup>\n ), overweight (BMI of 23.0 to 24.9 kg m\n \u22122<\/jats:sup>\n ), and obese (BMI of \u226525 kg m\n \u22122<\/jats:sup>\n ). The\n L. iners<\/jats:named-content>\n -dominant type had a significant association with obesity (odds ratio [OR], 7.55 [95% confidence interval [CI], 1.18 to 48.2]), compared to the\n L. crispatus<\/jats:named-content>\n -dominant type. The group with high values for the ratio obtained by dividing the relative abundance of\n L. iners<\/jats:named-content>\n by that of\n L. crispatus<\/jats:named-content>\n had a significant association with obesity (OR, 6.54 [95% CI, 1.22 to 35.1]), compared to the low-ratio group. Associations between obesity and the\n L. iners<\/jats:named-content>\n \/\n L. crispatus<\/jats:named-content>\n ratio were observed among young women (OR, 6.26 [95% CI, 1.15 to 33.9]) but not older women and in the normal group (OR, 6.97 [95% CI, 1.20 to 70.4]) but not the CIN group. Obesity was associated with cervical microflora dominated by\n L. iners<\/jats:named-content>\n in reproductive-age women without dysplasia.\n <\/jats:p>","DOI":"10.1128\/jcm.01387-15","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T02:29:43Z","timestamp":1439432983000},"page":"3304-3309","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Association between Obesity and Cervical Microflora Dominated by Lactobacillus iners in Korean Women"],"prefix":"10.1128","volume":"53","author":[{"given":"Hea Young","family":"Oh","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention, National Cancer Center, Ilsandong-gu, Goyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Soo","family":"Seo","sequence":"additional","affiliation":[{"name":"Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Sook","family":"Kong","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention, National Cancer Center, Ilsandong-gu, Goyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention, National Cancer Center, Ilsandong-gu, Goyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/315109"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.1.94"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115867"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002611107"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06041.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro794"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/429622"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep05136"},{"key":"e_1_3_3_10_2","first-page":"229","article-title":"Bacterial vaginosis: a review on clinical trials with probiotics","volume":"36","author":"Mastromarino P","year":"2013","unstructured":"Mastromarino P, Vitali B, Mosca L. 2013. Bacterial vaginosis: a review on clinical trials with probiotics. New Microbiol 36:229\u2013238.","journal-title":"New Microbiol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.162"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.104844"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-128"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096659"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00460-13"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.02.026"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9433-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063514"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-116"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012078"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00558-07"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem432"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11552"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12671"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00694-10"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.10.6199-6209.2005"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091090798"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2334-y"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0587"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2003.00038.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701515423"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01408-9"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.1.39"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045201"},{"key":"e_1_3_3_39_2","volume-title":"An introduction to medical statistics","author":"Bland M","year":"2001","unstructured":"Bland M. 2001. An introduction to medical statistics, 3rd ed. Oxford University Press, Oxford, United Kingdom.","edition":"3"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01387-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01387-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:00:24Z","timestamp":1646481624000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01387-15"}},"subtitle":[],"editor":[{"given":"E.","family":"Munson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1128\/JCM.01387-15"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01387-15","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"2015-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}