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RDTs are associated with early deescalation of therapy for Gram-positive BSIs. However, it is less clear how RDTs influence antibiotic management for Gram-negative BSIs and whether RDT results are acted on during off-hours. We performed a single-center, retrospective review of children with BSI and Verigene (VG) testing at a children\u2019s hospital. Of the 301 positive cultures included in the study (196 Gram-positive, 44 Gram-negative, 32 polymicrobial, and 29 non-VG targets), the VG result had potential to impact antibiotic selection in 171 cases; among these, antibiotic changes occurred in 119 (70%) cases.<\/jats:p>","DOI":"10.1128\/jcm.01400-19","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T10:48:19Z","timestamp":1576666099000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Impact of a Rapid Blood Culture Diagnostic Test in a Children's Hospital Depends on Gram-Positive versus Gram-Negative Organism and Day versus Night Shift"],"prefix":"10.1128","volume":"58","author":[{"given":"Lillian J.","family":"Juttukonda","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Katz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Gillon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathon","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703058"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu547"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw573"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ447"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1557"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.08.019"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit498"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.05.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.313"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0651-OA"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00376-16"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw649"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00095-17"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy308"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.175"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw118"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00053-14"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piw033"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0119-OA"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2014.09.025"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3343-2"},{"key":"e_1_3_3_23_2","volume-title":"Verigene Gram-negative blood culture nucleic acid test (BC-GN)","author":"Nanosphere","year":"2014","unstructured":"Nanosphere. 2014. 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