{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:36:14Z","timestamp":1792798574338,"version":"4.5.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Department of Defense, Orthopaedic Research Program","award":["W81XWH-15-1-0629"],"award-info":[{"award-number":["W81XWH-15-1-0629"]}],"id":[{"id":"https:\/\/ror.org\/03573qv54","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["PBZHP3_141483"],"award-info":[{"award-number":["PBZHP3_141483"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["P3MP3_148362\/1"],"award-info":[{"award-number":["P3MP3_148362\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2020,4,23]]},"abstract":"<jats:p>Prosthetic joint infections are difficult to diagnose and treat due to biofilm formation by the causative pathogens. Pathogen identification relies on microbial culture that requires days to weeks, and in the case of chronic biofilm infections, lacks sensitivity. Diagnosis of infection is often delayed past the point of effective treatment such that only the removal of the implant is curative. Early diagnosis of an infection based on antibody detection might lead to less invasive, early interventions.<\/jats:p>","DOI":"10.1128\/jcm.01414-19","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T09:16:15Z","timestamp":1581585375000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Development of a Novel and Rapid Antibody-Based Diagnostic for Chronic Staphylococcus aureus Infections Based on Biofilm Antigens"],"prefix":"10.1128","volume":"58","author":[{"given":"Janette M.","family":"Harro","sequence":"first","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Shirtliff","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland-Baltimore, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Arnold","sequence":"additional","affiliation":[{"name":"The Rothman Institute, Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Kofonow","sequence":"additional","affiliation":[{"name":"Northern Arizona University, Flagstaff, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Dammling","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Achermann","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA"},{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Zurich, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Brao","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland-Baltimore, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Parvizi","sequence":"additional","affiliation":[{"name":"The Rothman Institute, Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff G.","family":"Leid","sequence":"additional","affiliation":[{"name":"Northern Arizona University, Flagstaff, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.05.031"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.QMH.0000281058.99929.ea"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328301391d"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808939"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.03.010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(91)90043-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.15.2.167-193.2002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.03.036"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B9.34910"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00205"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2015.08.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4152-x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4297-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-2974-y"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.03.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00838"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3791\/51612"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.276075033"},{"key":"e_1_3_3_20_2","first-page":"20","article-title":"The radiology of infection","volume":"96","author":"Butt WP","year":"1973","unstructured":"Butt WP. 1973. The radiology of infection. Clin Orthop Relat Res 96:20\u201330.","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198904000-00003"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(05)70304-3"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/590011"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.10.3281-3290.1999"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/039139881003300902"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00210"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.9.3.508-514.2002"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01044-8"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-004-1100-1"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2019.01.009"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00392-06"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00451-10"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.2.253"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200208000-00027"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.46.1.231-233.2002"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199902000-00026"},{"key":"e_1_3_3_37_2","first-page":"581","volume-title":"Handbook of animal models of infection","author":"Shirtliff MEM","year":"1999","unstructured":"Shirtliff MEM, Mader JT. 1999. The rabbit model of bacterial osteomyelitis of the tibia, p 581\u2013591. In Zak O, Sande MA (ed), Handbook of animal models of infection. Academic Press Ltd., London, England."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00855-07"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.25.4.600-604.1987"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B11.33135"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00111-13"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2010.00766.x"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-999-4_7"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1918"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.11.010"},{"key":"e_1_3_3_46_2","first-page":"1027","article-title":"Diagnosis and management of osteomyelitis","volume":"84","author":"Hatzenbuehler J","year":"2011","unstructured":"Hatzenbuehler J, Pulling TJ. 2011. Diagnosis and management of osteomyelitis. Am Fam Physician 84:1027\u20131033.","journal-title":"Am Fam Physician"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0888-0"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-016-0476-8"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.12.3.387-398.2005"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1086\/599119"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1086\/596743"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.01.007"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis803"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2012.00938.x"},{"key":"e_1_3_3_55_2","first-page":"555","article-title":"Specific antibodies to Staphylococcus aureus biofilm are present in serum from pigs with osteomyelitis","volume":"29","author":"Jensen LK","year":"2015","unstructured":"Jensen LK, Jensen HE, Koch J, Bjarnsholt T, Eickhardt S, Shirtliff M. 2015. Specific antibodies to Staphylococcus aureus biofilm are present in serum from pigs with osteomyelitis. In Vivo 29:555\u2013560.","journal-title":"In Vivo"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01414-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01414-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T05:46:58Z","timestamp":1646459218000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01414-19"}},"subtitle":[],"editor":[{"given":"Yi-Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,23]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4,23]]}},"alternative-id":["10.1128\/JCM.01414-19"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01414-19","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,23]]},"assertion":[{"value":"2019-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01414-19"}}