{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:12:53Z","timestamp":1793373173497,"version":"4.5.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2023,2,22]]},"abstract":"<jats:p>\n            Differentiation between Whipple disease (WD) patients and patients carrying\n            <jats:named-content content-type=\"genus-species\">Tropheryma<\/jats:named-content>\n            <jats:named-content content-type=\"genus-species\">whipplei<\/jats:named-content>\n            but suffering from disease other than WD (\u201ccarriers\u201d) remains complex. We aimed to evaluate\n            <jats:named-content content-type=\"genus-species\">T. whipplei<\/jats:named-content>\n            PCR among patients with WD and carriers in a large cohort at our referral clinical microbiology laboratory. This is an observational retrospective cohort study, including all patients between 2008 and 2020 with at least one positive result for\n            <jats:named-content content-type=\"genus-species\">T. whipplei<\/jats:named-content>\n            using the real-time PCR RealCycler TRWH-UX kit. A total of 233 patients were included: 197 were considered carriers, and 36 had WD.\n          <\/jats:p>","DOI":"10.1128\/jcm.01457-22","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T14:01:19Z","timestamp":1674136879000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Contribution of PCR to Differential Diagnosis between Patients with Whipple Disease and Tropheryma whipplei Carriers"],"prefix":"10.1128","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-6093","authenticated-orcid":true,"given":"Sylvain","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, AP-HP Centre Universit\u00e9 de Paris Cit\u00e9, H\u00f4pital Necker-Enfants Malades, Paris, 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