{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:29:54Z","timestamp":1772162994724,"version":"3.50.1"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The first yellow-grain fungal mycetoma, in a 60-year-old man from Central Sudan, is reported. Morphological and phylogenetic analysis of the ribosomal small subunit (SSU), large subunit (LSU), internal transcribed spacer (ITS), \u03b2-tubulin (\n                    <jats:italic>BT2<\/jats:italic>\n                    ), actin (\n                    <jats:italic>ACT1<\/jats:italic>\n                    ), and elongation factor (\n                    <jats:italic>TEF1<\/jats:italic>\n                    ) genes revealed that the isolate deviated from any known agent of mycetoma; it clustered in the genus\n                    <jats:named-content content-type=\"genus-species\">Pleurostoma<\/jats:named-content>\n                    (anamorph genus,\n                    <jats:named-content content-type=\"genus-species\">Pleurostomophora<\/jats:named-content>\n                    ) in the order\n                    <jats:named-content content-type=\"genus-species\">Calosphaeriales<\/jats:named-content>\n                    . The novel species, here named\n                    <jats:named-content content-type=\"genus-species\">Pleurostomophora ochracea<\/jats:named-content>\n                    , is characterized by phenotypic features. The species proved to be highly susceptible to itraconazole, ketoconazole, posaconazole, and voriconazole, but not to fluconazole. The fungus was inhibited by caspofungin at 8 \u03bcg\/ml, while no inhibition was found with 5-flucytosine (MIC &gt; 64 \u03bcg\/ml). Compared to other members of the genus\n                    <jats:named-content content-type=\"genus-species\">Pleurostomophora<\/jats:named-content>\n                    ,\n                    <jats:named-content content-type=\"genus-species\">P. ochracea<\/jats:named-content>\n                    is slow growing, with a relatively high optimum growth temperature (36 to 37\u00b0C). This is the first case of a yellow-grain fungal mycetoma; yellow grains are otherwise of bacterial nature. Our case emphasizes that identification of mycetoma agents by the color of the grain only is not sufficient and may lead to inappropriate therapy.\n                  <\/jats:p>","DOI":"10.1128\/jcm.01470-12","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T18:38:01Z","timestamp":1341427081000},"page":"2987-2994","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Pleurostomophora ochracea, a Novel Agent of Human Eumycetoma with Yellow Grains"],"prefix":"10.1128","volume":"50","author":[{"given":"Najwa A.","family":"Mhmoud","sequence":"first","affiliation":[{"name":"Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Abdalla","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre, Utrecht, Netherlands"},{"name":"Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands"},{"name":"Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed H.","family":"Fahal","sequence":"additional","affiliation":[{"name":"Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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