{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:15:45Z","timestamp":1771460145137,"version":"3.50.1"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>We report a case of disseminated isoniazid-resistant tuberculosis in an immunocompromised patient with evolution of rifampin (rifampicin) resistance in the central nervous system. This was cured with intraventricular and oral treatment but was followed by a late relapse of the original infection in a prosthetic hip joint. We provide drug levels in cerebrospinal fluid and serum.<\/jats:p>","DOI":"10.1128\/jcm.01473-08","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T01:55:14Z","timestamp":1230170114000},"page":"507-510","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Evolution of Central Nervous System Multidrug-Resistant\n            <i>Mycobacterium tuberculosis<\/i>\n            and Late Relapse of Cryptic Prosthetic Hip Joint Tuberculosis: Complications during Treatment of Disseminated Isoniazid-Resistant Tuberculosis in an Immunocompromised Host"],"prefix":"10.1128","volume":"47","author":[{"given":"Arlo","family":"Upton","sequence":"first","affiliation":[{"name":"Clinical Microbiology, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Woodhouse","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandie","family":"Newton","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"Ellis-Pegler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"698","volume":"371","year":"2008","unstructured":"Anonymous. 2008. 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