{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:52:24Z","timestamp":1771008744553,"version":"3.50.1"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The purpose of this study was to evaluate the clinical utility of a quantitative\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            IgG assay for diagnosing chronic pulmonary aspergillosis. We examined\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            -specific IgG levels in patients who met the following criteria: (i) chronic (duration of &gt;3 months) pulmonary or systemic symptoms, (ii) radiological evidence of a progressive (over months or years) pulmonary lesion with surrounding inflammation, and (iii) no major discernible immunocompromising factors. Anti-\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            IgG serum levels were retrospectively analyzed according to defined classifications. Mean\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            IgG levels were significantly higher in the proven group than those in the possible and control groups (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). Receiver operating characteristic curve analysis revealed that the\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            IgG cutoff value for diagnosing proven cases was 50 mg of antigen-specific antibodies\/liter (area under the curve, 0.94; sensitivity, 0.98; specificity, 0.84). The sensitivity and specificity for diagnosing proven cases using this cutoff were 0.77 and 0.78, respectively. The positive rates of\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            IgG in the proven and possible groups were 97.9% and 39.2%, respectively, whereas that of the control group was 6.6%. The quantitative\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            IgG assay offers reliable sensitivity and specificity for diagnosing chronic pulmonary aspergillosis and may be an alternative to the conventional precipitin test.\n          <\/jats:p>","DOI":"10.1128\/jcm.01475-15","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T04:26:28Z","timestamp":1458793588000},"page":"1496-1499","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of a Quantitative Serological Assay for Diagnosing Chronic Pulmonary Aspergillosis"],"prefix":"10.1128","volume":"54","author":[{"given":"Satoru","family":"Fujiuchi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hokuto","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Doushita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadakatsu","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Fujikane","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization, Asahikawa Medical Center, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Osanai","sequence":"additional","affiliation":[{"name":"Cardiovascular Respiratory Frontier of Medical Renovation, Asahikawa Medical University, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Respiratory Center, Asahikawa Medical University, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Ohsaki","sequence":"additional","affiliation":[{"name":"Respiratory Center, Asahikawa Medical University, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054810"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.07.011"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0970-y"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2001.tb00006.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.067546"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12133"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/376526"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm.52.117"},{"key":"e_1_3_2_10_2","first-page":"581","article-title":"Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward","volume":"49","author":"Tashiro T","year":"2011","unstructured":"Tashiro T, Izumikawa K, Tashiro M, Takazono T, Morinaga Y, Yamamoto K, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Kohno S. 2011. Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward. Med Mycol 49:581\u2013587.","journal-title":"Med Mycol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.9142"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.01.014"},{"key":"e_1_3_2_13_2","first-page":"865","article-title":"Clinical analyses of Aspergillus infections in patients with underlying pulmonary disease","volume":"42","author":"Fujiuchi S","year":"2004","unstructured":"Fujiuchi S, Yamazaki Y, Matsumoto H, Yamamoto Y, Takeda A, Nishigaki Y, Fujita Y, Fujikane T, Shimizu T. 2004. Clinical analyses of Aspergillus infections in patients with underlying pulmonary disease. Nihon Kokyuki Gakkai Zasshi 42:865\u2013870. (In Japanese.)","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01548.x"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01475-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01475-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T08:53:03Z","timestamp":1646470383000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01475-15"}},"subtitle":[],"editor":[{"given":"Y.-W.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1128\/JCM.01475-15"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01475-15","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2015-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}