{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:22:15Z","timestamp":1790490135810,"version":"4.1.0"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Buruli ulcer is caused by\n                    <jats:named-content content-type=\"genus-species\">Mycobacterium ulcerans<\/jats:named-content>\n                    . This neglected disease occurs in scattered foci around the world, with a higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid-fast bacilli in smears or histopathology, culturing the mycobacteria, and performing\n                    <jats:named-content content-type=\"genus-species\">M. ulcerans<\/jats:named-content>\n                    PCR in presumptive cases confirm the diagnosis. Medical treatment with oral rifampin and intramuscular streptomycin or oral treatment with rifampin plus clarithromycin for 8 weeks is supported by the World Health Organization. This review summarizes the epidemiology, pathogenesis, clinical presentation, diagnostic tests, and advances in treatment.\n                  <\/jats:p>","DOI":"10.1128\/jcm.01507-17","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T06:12:36Z","timestamp":1515737556000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease"],"prefix":"10.1128","volume":"56","author":[{"given":"Jeannette","family":"Guarner","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","unstructured":"World Health Organization. 2017. Buruli ulcer ( Mycobacterium ulcerans infection). 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