{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:53:55Z","timestamp":1790834035855,"version":"4.1.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI007384"],"award-info":[{"award-number":["T32AI007384"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Syphilis screening with the reverse algorithm, a treponemal test for screening followed by a nontreponemal test if reactive, is increasingly being used. That algorithm has several advantages, including use of an automated screening test, saving on laboratory time and costs, as well as detection of very early syphilis infection. However, under that algorithm, in situations where the treponemal result is positive and the nontreponemal result is nonreactive a second treponemal test must be performed, which may actually lead to inefficiencies in the laboratory. In this issue of the\n            <jats:italic>Journal of Clinical Microbiology<\/jats:italic>\n            , Y. F. Fakile et al. (J Clin Microbiol 56:e01165-17, 2017,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/JCM.01165-17\">https:\/\/doi.org\/10.1128\/JCM.01165-17<\/jats:ext-link>\n            ) report the results of their study, which demonstrates the capability of signal strength ratio cutoffs for automated treponemal immunoassays to predict the outcome of repeat treponemal testing. Their findings suggest that anti-treponemal signal strength ratio values above a cutoff value can be used in lieu of repeat treponemal tests.\n          <\/jats:p>","DOI":"10.1128\/jcm.01555-17","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:25:41Z","timestamp":1508372741000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Using Treponemal Assay Signal Strength Cutoff Ratios To Predict Syphilis Infection"],"prefix":"10.1128","volume":"56","author":[{"given":"Claire C.","family":"Bristow","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases &amp; Global Public Health, Department of Medicine, University of California\u2014San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Klausner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California\u2014Los Angeles, Los Angeles, California, USA"},{"name":"Division of Infectious Diseases, Department of Medicine, University of California\u2014Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Sexually transmitted disease surveillance 2015","author":"Centers for Disease Control and Prevention","year":"2016","unstructured":"Centers for Disease Control and Prevention. 2016. Sexually transmitted disease surveillance 2015. Centers for Disease Control and Prevention, Atlanta, GA. https:\/\/www.cdc.gov\/std\/stats15\/STD-Surveillance-2015-print.pdf. Accessed 1 October 2017."},{"key":"e_1_3_3_3_2","first-page":"133","article-title":"Discordant results from reverse sequence syphilis screening\u2014five laboratories, United States, 2006\u20132010","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","unstructured":"Centers for Disease Control and Prevention. 2011. Discordant results from reverse sequence syphilis screening\u2014five laboratories, United States, 2006\u20132010. MMWR Morb Mortal Wkly Rep 60:133\u2013137.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181124473"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6404a1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01165-17"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215623806"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000066"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318205491a"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.165838"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24831"},{"key":"e_1_3_3_12_2","first-page":"1","article-title":"Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention","volume":"52","author":"Alter MJ","year":"2003","unstructured":"Alter MJ, Kuhnert WL, Finelli L. 2003. Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention. MMWR Recomm Rep 52:1\u201313, 15; quiz, CE1\u2013CE4.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_3_13_2","volume-title":"Guidelines for laboratory testing and result reporting","author":"Centers for Disease Control and Prevention","year":"2015","unstructured":"Centers for Disease Control and Prevention. 2015. Viral hepatitis. Guidelines for laboratory testing and result reporting. Centers for Disease Control and Prevention, Atlanta, GA. https:\/\/www.cdc.gov\/hepatitis\/hcv\/labtesting.htm. Accessed 1 October 2017."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/592696"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01555-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01555-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:15:24Z","timestamp":1646475324000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01555-17"}},"subtitle":[],"editor":[{"given":"Yi-Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1128\/JCM.01555-17"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01555-17","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01555-17"}}