{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:35:57Z","timestamp":1790325357274,"version":"4.1.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            If a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until intraoperative microbiological sampling has been performed. This practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. We aimed to assess the influence of antibiotic prophylaxis within 30 to 60 min before surgery on time to positivity of microbiological samples and on proportion of positive samples in\n            <jats:named-content content-type=\"genus-species\">Cutibacterium acnes<\/jats:named-content>\n            bone and joint infections. Patients with at least one sample positive for\n            <jats:named-content content-type=\"genus-species\">C. acnes<\/jats:named-content>\n            between January 2005 and December 2015 were included and classified as having an \u201cinfection\u201d if at least 2 samples were positive; otherwise they were considered to have a sample \u201ccontamination.\u201d Kaplan-Meier curves were used to illustrate time to culture positivity. We found 64 cases with a\n            <jats:named-content content-type=\"genus-species\">C. acnes<\/jats:named-content>\n            infection and 46 classified as having a\n            <jats:named-content content-type=\"genus-species\">C. acnes<\/jats:named-content>\n            contamination. Application of perioperative prophylaxis significantly differed between the infection and contamination groups (72.8% versus 55.8%;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Within the infection group, we found no difference in time to positivity between those who had or had not received a perioperative prophylaxis (7.07 days; 95% confidence interval [CI], 6.4 to 7.7, versus 7.11 days; 95% CI, 6.8 to 7.5;\n            <jats:italic>P<\/jats:italic>\n            = 0.3). Also, there was no association between the proportion of sample positivity and the application of perioperative prophylaxis (71.6% versus 65.9%;\n            <jats:italic>P<\/jats:italic>\n            = 0.39). Since perioperative prophylaxis did not negatively influence the microbiological yield in\n            <jats:named-content content-type=\"genus-species\">C. acnes<\/jats:named-content>\n            infections, antibiotic prophylaxis can be routinely given to avoid surgical site infections.\n          <\/jats:p>","DOI":"10.1128\/jcm.01576-17","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T16:30:24Z","timestamp":1511368224000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Perioperative Antibiotic Prophylaxis Has No Effect on Time to Positivity and Proportion of Positive Samples: a Cohort Study of 64 Cutibacterium acnes Bone and Joint Infections"],"prefix":"10.1128","volume":"56","author":[{"given":"Alexia","family":"Anagnostopoulos","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Bossard","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Ledergerber","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick O.","family":"Zingg","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, University Hospital Balgrist, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies S.","family":"Zinkernagel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, University Hospital Balgrist, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Achermann","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.9999"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260501"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/323130"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.12.011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MB-0010-2014"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01435-16"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.08.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040181"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2009.12.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis803"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1014-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e318065b780"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.09.014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3016-5"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.9314EBO"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666080-00005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199311000-00041"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00637"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00760-14"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.10.2932-2939.1998"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2012.02.022"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.41"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00775-08"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00640-17"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01576-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01576-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:11:26Z","timestamp":1646475086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01576-17"}},"subtitle":[],"editor":[{"given":"Robin","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1128\/JCM.01576-17"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01576-17","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"2017-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01576-17"}}