{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:28:42Z","timestamp":1789036122848,"version":"build-2803163510"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            spp. are a leading cause of diarrhea in Indian children, but there are no data for prevalent species or subgenotypes. Genetic characterization of\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            spp. by PCR-restriction fragment length polymorphism and spatial analysis of cases using Geographical Information Systems technology was carried out for 53 children with cryptosporidial diarrhea in an urban slum. The two most common species were\n            <jats:italic>C. hominis<\/jats:italic>\n            (81%) and\n            <jats:italic>C. parvum<\/jats:italic>\n            (12%). Other species identified were\n            <jats:italic>C. felis<\/jats:italic>\n            and\n            <jats:italic>C. parvum<\/jats:italic>\n            (mouse genotype). Five subgenotypes were identified at the\n            <jats:italic>Cpgp40\/15<\/jats:italic>\n            locus. Subgenotype Ia predominated among\n            <jats:italic>C. hominis<\/jats:italic>\n            isolates, and all\n            <jats:italic>C. parvum<\/jats:italic>\n            isolates were subgenotype Ic.\n            <jats:italic>C. hominis<\/jats:italic>\n            infection was associated with a greater severity of diarrhea. Sequencing of the\n            <jats:italic>Cpgp40\/15<\/jats:italic>\n            alleles of\n            <jats:italic>C. felis<\/jats:italic>\n            and\n            <jats:italic>C. parvum<\/jats:italic>\n            (mouse genotype) revealed similarities to subgenotype IIa and\n            <jats:italic>C. meleagridis<\/jats:italic>\n            , respectively. Space-time analysis revealed two clusters of infection due to\n            <jats:italic>C. hominis<\/jats:italic>\n            Ia, with a peak in February 2005. This is the first study to demonstrate space-time clustering of a single subgenotype of\n            <jats:italic>C. hominis<\/jats:italic>\n            in a setting where cryptosporidiosis is endemic. Molecular characterization and spatial analysis have the potential to further the understanding of disease and transmission in the community.\n          <\/jats:p>","DOI":"10.1128\/jcm.01590-06","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T05:51:58Z","timestamp":1169704318000},"page":"915-920","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":81,"title":["Molecular and Spatial Epidemiology of Cryptosporidiosis in Children in a Semiurban Community in South India"],"prefix":"10.1128","volume":"45","author":[{"given":"Sitara Swarna Rao","family":"Ajjampur","sequence":"first","affiliation":[{"name":"Departments of Gastrointestinal Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beryl Primrose","family":"Gladstone","sequence":"additional","affiliation":[{"name":"Community Health, Christian Medical College, Vellore TN 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Selvapandian","sequence":"additional","affiliation":[{"name":"Community Health, Christian Medical College, Vellore TN 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya Prakash","family":"Muliyil","sequence":"additional","affiliation":[{"name":"Community Health, Christian Medical College, Vellore TN 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honorine","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center, Tufts University School of Medicine, 750 Washington St., Boston, Massachusetts 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Kang","sequence":"additional","affiliation":[{"name":"Departments of Gastrointestinal Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"185","volume":"47","year":"2005","unstructured":"Caccio, S. 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