{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T11:59:37Z","timestamp":1648900777077},"reference-count":43,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Antimicrobial susceptibility testing (AST) assigns pathogens to \u201csusceptible\u201d or \u201cresistant\u201d clinical categories based on clinical breakpoints (CBPs) derived from MICs or inhibition zone diameters and indicates the likelihood for therapeutic success. AST reports do not provide quantitative measures for the reliability of such categorization. Thus, it is currently impossible for clinicians to estimate the technical forecast uncertainty of an AST result regarding clinical categorization. AST error rates depend on the localization of pathogen populations in relation to CBPs. Bacterial species are, however, not homogeneous, and subpopulations behave differently with respect to AST results. We addressed how AST reporting errors differ between isolates with and without acquired drug resistance determinants. Using as an example the beta-lactams and their most important resistance mechanisms, we analyzed different pathogen populations for their individual reporting error probabilities. Categorization error rates were significantly higher for bacterial populations harboring resistance mechanisms than for the wild-type population. Reporting errors for amoxicillin-clavulanic acid and piperacillin-tazobactam in\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            infection cases were almost exclusively due to the presence of broad-spectrum- and extended-spectrum-beta-lactamase (ESBL)-producing microorganisms (79% and 20% of all errors, respectively). Clinicians should be aware of the significantly increased risk of erroneous AST reports for isolates producing beta-lactamases, particularly ESBL and AmpC. Including probability indicators for interpretation would improve AST reports.\n          <\/jats:p>","DOI":"10.1128\/jcm.01645-14","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T06:05:27Z","timestamp":1407391527000},"page":"3674-3684","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Integrating Forecast Probabilities in Antibiograms: a Way To Guide Antimicrobial Prescriptions More Reliably?"],"prefix":"10.1128","volume":"52","author":[{"given":"Florian P.","family":"Maurer","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie, Universit\u00e4t Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Courvalin","sequence":"additional","affiliation":[{"name":"Unite des Agents Antibact\u00e9riens, Institut Pasteur, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik C.","family":"B\u00f6ttger","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie, Universit\u00e4t Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hombach","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie, Universit\u00e4t Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn357"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00047-06"},{"key":"e_1_3_2_4_2","volume-title":"Performance standards for antimicrobial susceptibility testing; 23rd informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2013","unstructured":"Clinical and Laboratory Standards Institute. 2013. Performance standards for antimicrobial susceptibility testing; 23rd informational supplement. CLSI document M 100-S 23. CLSI, Wayne, PA."},{"key":"e_1_3_2_5_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. EUCAST definitions of clinical breakpoints and epidemiological cut-off values. http:\/\/www.srga.org\/Eucastwt\/eucastdefinitions.htm. Accessed 11 June 2014."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinmicnews.2007.05.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1385\/MB:13:2:89"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12090"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1996.tb00872.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.suppl_1.87"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00061-10"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit017"},{"key":"e_1_3_2_13_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2013. Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1. http:\/\/www.eucast.org\/antimicrobial_susceptibility_testing\/previous_versions_of_tables\/. Accessed 11 June 2014."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03703.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(03)00107-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2011.01467.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01377.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt136"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis916"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks088"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt450"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir790"},{"key":"e_1_3_2_23_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. Disk diffusion manual v. 3.0. http:\/\/www.eucast.org\/antimicrobial_susceptibility_testing\/disk_diffusion_methodology\/. Accessed 11 June 2014."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-225"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00404-11"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03737.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00130-09"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq210"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq124"},{"key":"e_1_3_2_30_2","first-page":"515","volume-title":"Practical statistics for medical research, appendix B, table B1","author":"Altman DG","year":"1991","unstructured":"AltmanDG. 1991. Practical statistics for medical research, appendix B, table B1, p 515. Chapman & Hall\/CRC Texts in Statistical Science, London, United Kingdom."},{"key":"e_1_3_2_31_2","first-page":"46","volume-title":"Statistics with confidence","author":"Altman DG","year":"2000","unstructured":"AltmanDGNewcombeRG. 2000. Proportions and their differences and diagnostic tests, p 46\u201348, 106\u2013107. In AltmanDGMachinDBryantTNGardnerJM (ed), Statistics with confidence, 2nd ed. BMJ Books, London, United Kingdom.","edition":"2"},{"key":"e_1_3_2_32_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. EUCAST QC tables. http:\/\/www.eucast.org\/antimicrobial_susceptibility_testing\/qc_tables\/. Accessed 11 July 2014."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05913-11"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01265.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540210147516"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1086\/420816"},{"key":"e_1_3_2_37_2","volume-title":"Performance standards for antimicrobial susceptibility testing; 19th informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2009","unstructured":"Clinical and Laboratory Standards Institute. 2009. Performance standards for antimicrobial susceptibility testing; 19th informational supplement. CLSI document M 100-S 19. CLSI, Wayne, PA."},{"key":"e_1_3_2_38_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2008. Expert rules in antimicrobial susceptibility testing. Version 1. http:\/\/www.eucast.org\/expert_rules. Accessed 11 June 2014."},{"key":"e_1_3_2_39_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2013. Setting breakpoints for new agents EUCAST SOP 1.1. http:\/\/www.eucast.org\/documents\/sops\/. Accessed 11 June 2014."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00037-09"},{"key":"e_1_3_2_41_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. Breakpoint tables for interpretation of MICs and zone diameters. Version 4.0. http:\/\/www.eucast.org\/clinical_breakpoints\/. Accessed 11 June 2014."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.04.006"},{"key":"e_1_3_2_43_2","unstructured":"European Centre for Disease Prevention and Control network. 2014. Antimicrobial resistance interactive database (EARS-Net). http:\/\/www.ecdc.europa.eu\/en\/healthtopics\/antimicrobial_resistance\/database\/Pages\/database.aspx. Accessed 11 June 2014."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.05.015"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01645-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01645-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:42:04Z","timestamp":1646480524000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01645-14"}},"subtitle":[],"editor":[{"given":"G. A.","family":"Land","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1128\/JCM.01645-14"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01645-14","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"2014-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}