{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T20:18:24Z","timestamp":1767730704664,"version":"build-2238731810"},"reference-count":9,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n                    is a common cause of bacteremia, with a substantial impact on morbidity and mortality. Because of increasing rates of methicillin-resistant\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n                    , vancomycin has become the standard empirical therapy. However, beta-lactam antibiotics remain the best treatment choice for methicillin-susceptible strains. Placing patients quickly on the optimal therapy is one goal of antimicrobial stewardship. This retrospective, observational, single-center study compared 33 control patients utilizing only traditional full-susceptibility methodology to 22 case patients utilizing rapid methodology with CHROMagar medium to detect and differentiate methicillin-resistant and methicillin-susceptible\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n                    strains hours before full susceptibilities were reported. The time to targeted therapy was statistically significantly different between control patients (mean, 56.5 \u00b1 13.6 h) and case patients (44.3 \u00b1 17.9 h) (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.006). Intensive care unit status, time of day results emerged, and patient age did not make a difference in time to targeted therapy, either singly or in combination. Neither length of stay (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.61) nor survival (\n                    <jats:italic>P<\/jats:italic>\n                    = 1.0) was statistically significantly different. Rapid testing yielded a significant result, with a difference of 12.2 h to targeted therapy. However, there is still room for improvement, as the difference in time to susceptibility test result between the full traditional methodology and CHROMagar was even larger (26.5 h). This study supports the hypothesis that rapid testing plays a role in antimicrobial stewardship by getting patients on targeted therapy faster.\n                  <\/jats:p>","DOI":"10.1128\/jcm.01667-13","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T21:00:40Z","timestamp":1380747640000},"page":"4126-4129","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Outcomes with Rapid Detection of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Isolates from Routine Blood Cultures"],"prefix":"10.1128","volume":"51","author":[{"given":"Nicole C.","family":"Nicolsen","sequence":"first","affiliation":[{"name":"UNC Health Care, Department of Pharmacy, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"LeCroy","sequence":"additional","affiliation":[{"name":"UNC Health Care, Department of Pharmacy, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Alby","sequence":"additional","affiliation":[{"name":"UNC Health Care, Clinical Microbiology Laboratory, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Laux","sequence":"additional","affiliation":[{"name":"North Carolina Translational and Clinical Sciences Institute, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"North Carolina Translational and Clinical Sciences Institute, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Daniels","sequence":"additional","affiliation":[{"name":"UNC Health Care, Department of Pharmacy, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Weber","sequence":"additional","affiliation":[{"name":"UNC School of Medicine, Department of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa B.","family":"Miller","sequence":"additional","affiliation":[{"name":"UNC Health Care, Clinical Microbiology Laboratory, Chapel Hill, North Carolina, USA"},{"name":"UNC School of Medicine, Department of Pathology and Laboratory Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2004.05.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-5-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05022-11"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.19.2229"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-279"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.04.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/636502"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110724"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110604"}],"updated-by":[{"DOI":"10.1128\/jcm.00866-14","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000}}],"container-title":["Journal of Clinical 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