{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:37:23Z","timestamp":1790854643342,"version":"4.1.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In North America, Lyme borreliosis (LB) is a tick-borne disease caused by infection with the spirochete\n            <jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>\n            . We studied the genetic diversity of LB spirochetes in north-coastal California residents. Spirochete DNA was detected in 23.7% (27\/114) of the study subjects using a PCR protocol optimized for increased sensitivity in human sera. Californians were most commonly infected with\n            <jats:italic>B. burgdorferi ospC<\/jats:italic>\n            genotype A, a globally widespread spirochete associated with high virulence in LB patients. Sequence analysis of\n            <jats:italic>rrf-rrl<\/jats:italic>\n            and\n            <jats:italic>p66<\/jats:italic>\n            loci in 11% (3\/27) of the PCR-positive study subjects revealed evidence of infection with an organism closely related to\n            <jats:named-content content-type=\"genus-species\">B. bissettii<\/jats:named-content>\n            . This spirochete, heretofore associated with LB only in Europe, is widely distributed among ticks and wildlife in North America. Further molecular testing of sera from residents in areas where LB is endemic is warranted to enhance our understanding of the geographic distribution and frequency of occurrence of\n            <jats:named-content content-type=\"genus-species\">B. bissettii<\/jats:named-content>\n            -like infections.\n          <\/jats:p>","DOI":"10.1128\/jcm.01689-10","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T03:29:27Z","timestamp":1293074967000},"page":"945-954","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Genetic Diversity of Borrelia burgdorferi and Detection of B. bissettii-Like DNA in Serum of North-Coastal California Residents"],"prefix":"10.1128","volume":"49","author":[{"given":"Yvette A.","family":"Girard","sequence":"first","affiliation":[{"name":"Department of Environmental Science, Policy and Management, University of California, Berkeley, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Department of Environmental Science, Policy and Management, University of California, Berkeley, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Environmental Science, Policy and Management, University of California, Berkeley, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.484-509.2005"},{"key":"e_1_3_2_3_2","first-page":"1","article-title":"Surveillance for Lyme disease\u2014United States, 1992\u20132006","volume":"57","author":"Bacon R. 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