{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:11:00Z","timestamp":1790673060284,"version":"4.1.0"},"reference-count":71,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["DH140195"],"award-info":[{"award-number":["DH140195"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["109385\/Z\/15\/Z"],"award-info":[{"award-number":["109385\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"RCUK | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L502479\/1"],"award-info":[{"award-number":["BB\/L502479\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"RCUK | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/G019274\/1"],"award-info":[{"award-number":["BB\/G019274\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p><jats:named-content content-type=\"genus-species\">Streptococcus suis<\/jats:named-content>is one of the most important zoonotic bacterial pathogens of pigs, causing significant economic losses to the global swine industry.<jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>is also a very successful colonizer of mucosal surfaces, and commensal strains can be found in almost all pig populations worldwide, making detection of the<jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>species in asymptomatic carrier herds of little practical value in predicting the likelihood of future clinical relevance.<\/jats:p>","DOI":"10.1128\/jcm.01712-18","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T07:51:34Z","timestamp":1554191494000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Pathotyping the Zoonotic Pathogen Streptococcus suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales"],"prefix":"10.1128","volume":"57","author":[{"given":"Thomas M.","family":"Wileman","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy A.","family":"Weinert","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-920X","authenticated-orcid":false,"given":"Kate J.","family":"Howell","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna M.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Animal and Plant Health Agency, Bury St Edmunds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry M.","family":"Wells","sequence":"additional","affiliation":[{"name":"Host-Microbe Interactomics, Department of Animal Sciences, Wageningen Univeristy, Wageningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Langford","sequence":"additional","affiliation":[{"name":"Section of Paediatrics, Department of Medicine, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Rycroft","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College, Hawkshead Campus, Hatfield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan W.","family":"Wren","sequence":"additional","affiliation":[{"name":"Faculty of Infectious &amp; Tropical Diseases, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan J.","family":"Maskell","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander W.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005870317757"},{"key":"e_1_3_3_3_2","first-page":"841","volume-title":"Diseases of swine","author":"Gottschalk M","year":"2012","unstructured":"Gottschalk M. 2012. Streptococcosis, p 841\u2013855. In Zimmerman J, Karriker L, Ramirez A, Schwartz K, Stevenson G (ed), Diseases of swine, 10th ed. John Wiley & Sons, Inc, New York NY.","edition":"10"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.26444\/aaem\/85651"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1968.tb03456.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/527385"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2102.140961"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2014.06.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.107.2.40"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-018-1116-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2014.45"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.069757-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.06.024"},{"key":"e_1_3_3_16_2","first-page":"461","article-title":"Distribution of Streptococcus suis capsular types from 2001 to 2007","volume":"49","author":"Messier S","year":"2008","unstructured":"Messier S, Lacouture S, Gottschalk M, Groupe de Recherche sur les Maladies Infectieuses du Porc (GREMIP), Centre de Recherche en Infectiologie Porcine (CRIP). 2008. Distribution of Streptococcus suis capsular types from 2001 to 2007. Can Vet J 49:461\u2013462.","journal-title":"Can Vet J"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.148.7.207"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(00)00188-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.17.6.993-996.1983"},{"key":"e_1_3_3_20_2","first-page":"1037","article-title":"Differences in virulence between 2 strains of Streptococcus suis type II after experimentally induced infection of newborn germ-free pigs","volume":"50","author":"Vecht U","year":"1989","unstructured":"Vecht U, Arends JP, Vandermolen EJ, Vanleengoed L. 1989. Differences in virulence between 2 strains of Streptococcus suis type II after experimentally induced infection of newborn germ-free pigs. Am J Vet Res 50:1037\u20131043.","journal-title":"Am J Vet Res"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.2.550-556.1992"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.04.024"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00359-06"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-010-9643-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.149"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.02.005"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.8.3318-3326.1993"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.9.3156-3162.1991"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.5.1742-1748.1994"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.137.12.295"},{"key":"e_1_3_3_31_2","first-page":"75","article-title":"Production of virulence-related proteins by Canadian strains of Streptococcus suis capsular type 2","volume":"62","author":"Gottschalk M","year":"1998","unstructured":"Gottschalk M, Lebrun A, Wisselink H, Dubreuil JD, Smith H, Vecht U. 1998. Production of virulence-related proteins by Canadian strains of Streptococcus suis capsular type 2. Can J Vet Res 62:75\u201379.","journal-title":"Can J Vet Res"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.10.4409-4412.1996"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006072"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00535-13"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137760"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7740"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150908"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00536-14"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.10.3671-3680.2002"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2006.06.003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0109-z"},{"key":"e_1_3_3_42_2","volume-title":"Studies of Streptococcus suis type 2 infection in pigs","author":"Clifton-Hadley FA","year":"1981","unstructured":"Clifton-Hadley FA. 1981. Studies of Streptococcus suis type 2 infection in pigs. University of Cambridge, Cambridge, United Kingdom."},{"key":"e_1_3_3_43_2","volume-title":"R: a language and environment for statistical computing","author":"R Development Core Team","year":"2008","unstructured":"R Development Core Team. 2008. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.2008.130"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-11-94"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn129"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr521"},{"key":"e_1_3_3_48_2","unstructured":"Heinze G Ploner M Dunkler D Southworth H. 2013 logistf: Firth\u2019s bias reduced logistic regression. https:\/\/rdrr.io\/cran\/logistf\/man\/logistf.html."},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti623"},{"key":"e_1_3_3_50_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2014","unstructured":"R Core Team. 2014. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1227"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072070"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-016-0782-8"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2014.09.003"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2005.12.013"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06094-11"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5587"},{"key":"e_1_3_3_58_2","doi-asserted-by":"crossref","unstructured":"Stock C Hielscher T. 2014. DTComPair: comparison of binary diagnostic tests in a paired study design. http:\/\/CRAN.R-project.org\/package=DTComPair.","DOI":"10.32614\/CRAN.package.DTComPair"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(00)00250-9"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.14"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.15"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3169-3175.2004"},{"key":"e_1_3_3_63_2","first-page":"14","article-title":"Detection and molecular typing of Streptococcus suis in tonsils from live pigs in France","volume":"71","author":"Marois C","year":"2007","unstructured":"Marois C, Le Devendec L, Gottschalk M, Kobisch M. 2007. Detection and molecular typing of Streptococcus suis in tonsils from live pigs in France. Can J Vet Res 71:14\u201322.","journal-title":"Can J Vet Res"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.01.009"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1168"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4mt00327f"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens5040062"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28984"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00044-12"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005854"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6055"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elt015"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01712-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01712-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T10:30:44Z","timestamp":1721125844000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01712-18"}},"subtitle":[],"editor":[{"given":"Brad","family":"Fenwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":71,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1128\/JCM.01712-18"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01712-18","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2018-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01712-18"}}