{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:55:17Z","timestamp":1781805317371,"version":"3.54.5"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Increasing entomologic and epidemiologic evidence suggests that spotted fever group rickettsiae (SFGR) other than\n                    <jats:named-content content-type=\"genus-species\">Rickettsia rickettsii<\/jats:named-content>\n                    are responsible for spotted fever rickettsioses in the United States. A retrospective seroepidemiologic study was conducted on stored acute- and convalescent-phase sera that had been submitted for Rocky Mountain spotted fever testing to the North Carolina State Laboratory of Public Health. We evaluated the serologic reactivity of the paired sera to\n                    <jats:named-content content-type=\"genus-species\">R. rickettsii<\/jats:named-content>\n                    ,\n                    <jats:named-content content-type=\"genus-species\">Rickettsia parkeri<\/jats:named-content>\n                    , and\n                    <jats:named-content content-type=\"genus-species\">Rickettsia amblyommii<\/jats:named-content>\n                    antigens. Of the 106 eligible pairs tested, 21 patients seroconverted to one or more antigens. Cross-reactivity to multiple antigens was observed in 10 patients, and seroconversions to single antigens occurred in 11 patients, including 1 against\n                    <jats:named-content content-type=\"genus-species\">R. rickettsii<\/jats:named-content>\n                    , 4 against\n                    <jats:named-content content-type=\"genus-species\">R. parkeri<\/jats:named-content>\n                    , and 6 against\n                    <jats:named-content content-type=\"genus-species\">R. amblyommii<\/jats:named-content>\n                    . Cross-absorption of cross-reactive sera and\/or Western blots identified two presumptive cases of infection with\n                    <jats:named-content content-type=\"genus-species\">R. parkeri<\/jats:named-content>\n                    , two presumptive cases of infection with\n                    <jats:named-content content-type=\"genus-species\">R. rickettsii<\/jats:named-content>\n                    , and one presumptive case of infection with\n                    <jats:named-content content-type=\"genus-species\">R. amblyommii<\/jats:named-content>\n                    . These findings suggest that species of SFGR other than\n                    <jats:named-content content-type=\"genus-species\">R. rickettsii<\/jats:named-content>\n                    are associated with illness among North Carolina residents and that serologic testing using\n                    <jats:named-content content-type=\"genus-species\">R. rickettsii<\/jats:named-content>\n                    antigen may miss cases of spotted fever rickettsioses caused by other species of SFGR.\n                  <\/jats:p>","DOI":"10.1128\/jcm.01733-14","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T13:44:53Z","timestamp":1409838293000},"page":"3960-3966","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Seroepidemiologic Study of Human Infections with Spotted Fever Group Rickettsiae in North Carolina"],"prefix":"10.1128","volume":"52","author":[{"given":"Meagan F.","family":"Vaughn","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josie","family":"Delisle","sequence":"additional","affiliation":[{"name":"Tennessee Department of Health, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey","family":"Johnson","sequence":"additional","affiliation":[{"name":"North Carolina State Laboratory of Public Health, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaylen","family":"Daves","sequence":"additional","affiliation":[{"name":"North Carolina State Laboratory of Public Health, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Williams","sequence":"additional","affiliation":[{"name":"North Carolina Division of Public Health, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Reber","sequence":"additional","affiliation":[{"name":"North Carolina Division of Public Health, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Mendell","sequence":"additional","affiliation":[{"name":"Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Center for Tropical Diseases, University of Texas Medical Branch at Galveston, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Bouyer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Center for Tropical Diseases, University of Texas Medical Branch at Galveston, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abelardo C.","family":"Moncayo","sequence":"additional","affiliation":[{"name":"Tennessee Department of Health, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Meshnick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"1","volume":"60","author":"Adams DA","year":"2013","unstructured":"AdamsDAGallagherKMJajoskyRAKrisemanJSharpPAndersonWJAranasAEMayesMWodajoMSOnwehDHAbelleraJPDivision of Notifiable Diseases and Healthcare Information, Office of Surveillance, Epidemiology, and Laboratory Services, CDC. 2013. 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