{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:47:57Z","timestamp":1791305277166,"version":"4.3.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Staphylococcus lugdunensis<\/jats:italic>\n            is a coagulase-negative staphylococcus that has several similarities to\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            .\n            <jats:italic>S. lugdunensis<\/jats:italic>\n            is increasingly being recognized as a cause of prosthetic joint infection (PJI). The goal of the present retrospective cohort study was to determine the laboratory and clinical characteristics of\n            <jats:italic>S. lugdunensis<\/jats:italic>\n            PJIs seen at the Mayo Clinic in Rochester, MN, between 1 January 1998 and 31 December 2007. Kaplan-Meier survival methods and Wilcoxon sum-rank analysis were used to determine the cumulative incidence of treatment success and assess subset comparisons. There were 28 episodes of\n            <jats:italic>S<\/jats:italic>\n            .\n            <jats:italic>lugdunensis<\/jats:italic>\n            PJIs in 22 patients; half of those patients were females. Twenty-five episodes (89%) involved the prosthetic knee, while 3 (11%) involved the hip. Nine patients (32%) had an underlying urogenital abnormality. Among the 28 isolates in this study tested by agar dilution, 24 of 28 (86%) were oxacillin susceptible. Twenty of the 21 tested isolates (95%) lacked\n            <jats:italic>mecA<\/jats:italic>\n            , and 6 (27%) of the 22 isolates tested produced \u03b2-lactamase. The median durations of parenteral \u03b2-lactam therapy and vancomycin therapy were 38 days (range, 23 to 42 days) and 39 days (range, 12 to 60 days), respectively. The cumulative incidences of freedom from treatment failure (standard deviations) at 2 years were 92% (\u00b17%) and 76% (\u00b112%) for episodes treated with a parenteral \u03b2-lactam and vancomycin, respectively (\n            <jats:italic>P<\/jats:italic>\n            = 0.015).\n            <jats:italic>S. lugdunensis<\/jats:italic>\n            is increasingly being recognized as a cause of PJIs. The majority of the isolates lacked\n            <jats:italic>mecA<\/jats:italic>\n            . Episodes treated with a parenteral \u03b2-lactam antibiotic appear to have a more favorable outcome than those treated with parenteral vancomycin.\n          <\/jats:p>","DOI":"10.1128\/jcm.01769-09","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T05:30:02Z","timestamp":1267075802000},"page":"1600-1603","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Laboratory and Clinical Characteristics of\n            <i>Staphylococcus lugdunensis<\/i>\n            Prosthetic Joint Infections"],"prefix":"10.1128","volume":"48","author":[{"given":"Neel B.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Osmon","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind","family":"Fadel","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease"},{"name":"Division of Clinical Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy C.","family":"Kohner","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Steckelberg","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tad","family":"Mabry","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie F.","family":"Berbari","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/383318"},{"key":"e_1_3_1_3_2","unstructured":"Reference deleted."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119698"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(89)90044-2"},{"key":"e_1_3_1_6_2","unstructured":"Reference deleted."},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-38-2-168"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.12.2434"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.3.419-421.1991"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.752-754.2000"},{"key":"e_1_3_1_11_2","first-page":"177","volume":"41","year":"2000","unstructured":"Ling, M. L., and M. Yeo. 2000. Staphylococcus lugdunensis: report of first case of skin and soft tissue infection in Singapore. Singapore Med. J.41:177-178.","journal-title":"Singapore Med. J."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.1.197"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.4.993-994.1996"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.11.4262-4263.2000"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00137-06"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)64220-1"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0953-z"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.8.1948-1952.1992"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00740-08"},{"key":"e_1_3_1_20_2","first-page":"S75","volume":"85","year":"2003","unstructured":"Tsukayama, D. T., V. M. Goldberg, and R. Kyle. 2003. Diagnosis and management of infection after total knee arthroplasty. J. Bone Joint Surg. Am.85:S75-S80.","journal-title":"J. Bone Joint Surg. 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