{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:37:46Z","timestamp":1773286666199,"version":"3.50.1"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Scrub typhus, caused by\n            <jats:italic>Orientia tsutsugamushi<\/jats:italic>\n            , has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100%), headache (82%), myalgias (77%), eschar (67%), rash (52%), and unusual facial flushing (62%). Among the 104 patients, the sera of 98% contained IgM antibodies to\n            <jats:italic>O. tsutsugamushi<\/jats:italic>\n            detected by indirect immunofluorescence assays (IFA), and DNA of the\n            <jats:italic>O. tsutsugamushi<\/jats:italic>\n            56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past.\n          <\/jats:p>","DOI":"10.1128\/jcm.01784-09","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T02:24:21Z","timestamp":1265250261000},"page":"1241-1244","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Scrub Typhus in Previously Unrecognized Areas of Endemicity in China"],"prefix":"10.1128","volume":"48","author":[{"given":"Shouyin","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, China Centers for Disease Control and Prevention, Beijing 102206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Song","sequence":"additional","affiliation":[{"name":"PLA Institute of Disease Control and Prevention, Beijing 100071"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Center for Disease Control and Prevention, Hefei, Anhui 230061"},{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Centers for Disease Control and Prevention, Beijing 100050"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"PLA Institute of Disease Control and Prevention, Beijing 100071"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabin","family":"Wu","sequence":"additional","affiliation":[{"name":"Anhui Center for Disease Control and Prevention, Hefei, Anhui 230061"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Wan","sequence":"additional","affiliation":[{"name":"Fuyang City Center for Disease Control and Prevention"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolan","family":"Li","sequence":"additional","affiliation":[{"name":"Fuyang City Center for Disease Control and Prevention"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Fuyang City Center for Disease Control and Prevention"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyong","family":"Li","sequence":"additional","affiliation":[{"name":"Second People's Hospital of Fuyang City, Fuyang City, Anhhui 236030, 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