{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:22:51Z","timestamp":1780492971421,"version":"3.54.1"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The veterinary pathogens in the\n            <jats:named-content content-type=\"genus-species\">Staphylococcus intermedius<\/jats:named-content>\n            group (SIG) are increasingly recognized as causes of human infection. Shared features between SIG and\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            may result in the misidentification of SIG in human clinical cultures. This study examined the clinical and microbiological characteristics of isolates recovered at a tertiary-care academic medical center. From 2013 to 2015, 81 SIG isolates were recovered from 62 patients. Patients were commonly \u226550 years old, diabetic, and\/or immunocompromised. Documentation of dog exposure in the electronic medical record was not common. Of the 81 SIG isolates, common sites of isolation included 37 (46%) isolates from wound cultures and 17 (21%) isolates from respiratory specimens. Although less common, 10 (12%) bloodstream infections were documented in 7 unique patients. The majority of SIG (65%) isolates were obtained from polymicrobial cultures. In comparison to\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            isolates from the same time period, significant differences were noted in proportion of SIG isolates that were susceptible to doxycycline (74% versus 97%, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), trimethoprim-sulfamethoxazole (65% versus 97%, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), and ciprofloxacin (78% versus 59%, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). Methicillin resistance (MR) was detected in 12 (15%) of 81 SIG isolates. All MR isolates detected by an oxacillin disk diffusion test would have been misclassified as methicillin susceptible using a cefoxitin disk diffusion test. Thus, SIG is recovered from human clinical specimens, and distinction of SIG from\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            is critical for the accurate characterization of MR status in these isolates.\n          <\/jats:p>","DOI":"10.1128\/jcm.01788-17","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T12:14:44Z","timestamp":1515413684000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Epidemiology, Clinical Characteristics, and Antimicrobial Susceptibility Profiles of Human Clinical Isolates of Staphylococcus intermedius Group"],"prefix":"10.1128","volume":"56","author":[{"given":"Melanie L.","family":"Yarbrough","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9372-6737","authenticated-orcid":false,"given":"William","family":"Lainhart","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1137-840X","authenticated-orcid":false,"given":"Carey-Ann D.","family":"Burnham","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02474-14"},{"key":"e_1_3_1_3_2","first-page":"340","volume-title":"Infectious diseases of the dog and cat","author":"Weese JS","year":"2012","unstructured":"Weese JS. 2012. Staphylococcal infections, p 340\u2013348. In Greene CE (ed), Infectious diseases of the dog and cat, 4th ed. 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