{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:00:49Z","timestamp":1767164449547,"version":"build-2238731810"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>\n                    ,\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , and\n                    <jats:italic>Tannerella forsythia<\/jats:italic>\n                    are oral pathogens associated with periodontitis. The association between these three bacteria and periodontal disease has been reported in populations of many countries. However, corresponding data in Chinese populations are still lacking. The aim of this study was to detect these pathogens in subgingival plaque collected from 468 subjects with chronic periodontitis in a group of Chinese adults by using a PCR method and to determine the degree of association between the target bacteria and periodontal status based on logistic regression analysis.\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    ,\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    , and\n                    <jats:italic>T. forsythia<\/jats:italic>\n                    were found in 20.5%, 70.7%, and 77.1% of the subjects, respectively. About one-third (36.1%) of subjects had chronic periodontitis. Upon univariate analysis, age, male gender, current smoking status, diabetes, and the presence of\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    or\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    were positively associated with chronic periodontitis, whereas education and income exhibited inverse associations with chronic periodontitis. Upon multivariate analysis, education, current smoking status, diabetes, and the presence of\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    and\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    remained significant. The adjusted odds ratios for having chronic periodontitis were 2.5 and 3.4 in subjects positive for\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    and\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    , respectively. However, no significant association was observed between the presence of\n                    <jats:italic>T. forsythia<\/jats:italic>\n                    and periodontal status. This study assesses the prevalence of periodontal pathogens and chronic periodontitis and the associations with sociodemographic characteristics among this group of Chinese adults. These findings also suggest that PCR should be considered for field oral epidemiologic studies and may be necessary in investigations presenting major logistic challenges.\n                  <\/jats:p>","DOI":"10.1128\/jcm.01819-10","type":"journal-article","created":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T23:09:55Z","timestamp":1290640195000},"page":"184-188","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Association of Three Bacterial Species and Periodontal Status in Chinese Adults: an Epidemiological Approach"],"prefix":"10.1128","volume":"49","author":[{"given":"Tianzheng","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Stomatology, General Hospital of the Air Force of the Chinese People's Liberation Army, No. 30 Fucheng Road, Haidian District, Beijing 100142, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Geriatric Cardiology, People's Liberation Army General Hospital, Fuxing Road 28, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Stomatology, General Hospital of the Air Force of the Chinese People's Liberation Army, No. 30 Fucheng Road, Haidian District, Beijing 100142, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianliang","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, General Hospital of the Air Force of the Chinese People's Liberation Army, No. 30 Fucheng Road, Haidian District, Beijing 100142, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, General Hospital of the Air Force of the Chinese People's Liberation Army, No. 30 Fucheng Road, Haidian District, Beijing 100142, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine, Stomatology Center, People's Liberation Army General Hospital, Fuxing Road 28, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Stomatology, General Hospital of the Air Force of the Chinese People's Liberation Army, No. 30 Fucheng Road, Haidian District, Beijing 100142, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Amano A. 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