{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:52:11Z","timestamp":1791294731639,"version":"4.1.0"},"reference-count":61,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The food-borne pathogen\n            <jats:named-content content-type=\"genus-species\">Listeria monocytogenes<\/jats:named-content>\n            is genetically heterogeneous. Although some clonal groups have been implicated in multiple outbreaks, there is currently no consensus on how \u201cepidemic clones\u201d should be defined. The objectives of this work were to compare the patterns of sequence diversity on two sets of genes that have been widely used to define\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            clonal groups: multilocus sequence typing (MLST) and multi-virulence-locus sequence typing (MvLST). Further, we evaluated the diversity within clonal groups by pulsed-field gel electrophoresis (PFGE). Based on 125 isolates of diverse temporal, geographical, and source origins, MLST and MvLST genes (i) had similar patterns of sequence polymorphisms, recombination, and selection, (ii) provided concordant phylogenetic clustering, and (iii) had similar discriminatory power, which was not improved when we combined both data sets. Inclusion of representative strains of previous outbreaks demonstrated the correspondence of epidemic clones with previously recognized MLST clonal complexes. PFGE analysis demonstrated heterogeneity within major clones, most of which were isolated decades before their involvement in outbreaks. We conclude that the \u201cepidemic clone\u201d denominations represent a redundant but largely incomplete nomenclature system for MLST-defined clones, which must be regarded as successful genetic groups that are widely distributed across time and space.\n          <\/jats:p>","DOI":"10.1128\/jcm.01874-13","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T01:47:03Z","timestamp":1378345623000},"page":"3770-3779","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":133,"title":["\u201cEpidemic Clones\u201d of Listeria monocytogenes Are Widespread and Ancient Clonal Groups"],"prefix":"10.1128","volume":"51","author":[{"given":"Thomas","family":"Cantinelli","sequence":"first","affiliation":[{"name":"Institut Pasteur, French National Reference Center for Listeria and WHO Collaborating Center for Listeria, Biology of Infection Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Chenal-Francisque","sequence":"additional","affiliation":[{"name":"Institut Pasteur, French National Reference Center for Listeria and WHO Collaborating Center for Listeria, Biology of Infection Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Diancourt","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Frezal","sequence":"additional","affiliation":[{"name":"Institute of Biology of the Ecole Normale Sup\u00e9rieure, CNRS UMR8197, INSERM U1024, Ecole Normale Sup\u00e9rieure, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Institut Pasteur, French National Reference Center for Listeria and WHO Collaborating Center for Listeria, Biology of Infection Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Wirth","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Integrative, Ecole Pratique des Hautes Etudes, Paris, France"},{"name":"Mus\u00e9um National d'Histoire Naturelle, UMR-CNRS 7205, D\u00e9partement Syst\u00e9matique et Evolution, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lecuit","sequence":"additional","affiliation":[{"name":"Institut Pasteur, French National Reference Center for Listeria and WHO Collaborating Center for Listeria, Biology of Infection Unit, Paris, France"},{"name":"Inserm U1117, Institut Pasteur, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Assistance Publique-H\u00f4pitaux de Paris, Service des Maladies Infectieuses et Tropicales, H\u00f4pital Universitaire Necker-Enfants Malades, Institut Imagine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Brisse","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Microbial Evolutionary Genomics, Paris, France"},{"name":"CNRS, UMR3525, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"DennyJMcLauchlinJ. 2008. 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