{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:34:37Z","timestamp":1787668477013,"version":"build-2736575974"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There are currently no commercially available molecular assays for the detection of\n                    <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n                    in rectal swabs with regulatory approval. We compared the Cepheid GeneXpert CT\/NG assay with the GenProbe Aptima Combo2 assay, using 409 rectal swabs. Using Aptima as the gold standard, the sensitivity, specificity, and positive and negative predictive values of GeneXpert for the detection of\n                    <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n                    were 86%, 99.2%, 92.5%, and 98.4% and 91.1%, 100%, 100%, and 98.6%, respectively. Despite significant dilution of samples prior to GeneXpert testing, the assay performed well with excellent specificity.\n                  <\/jats:p>","DOI":"10.1128\/jcm.01930-12","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T21:34:44Z","timestamp":1348090484000},"page":"3867-3869","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Performance of the GeneXpert CT\/NG Assay Compared to That of the Aptima AC2 Assay for Detection of Rectal Chlamydia trachomatis and Neisseria gonorrhoeae by Use of Residual Aptima Samples"],"prefix":"10.1128","volume":"50","author":[{"given":"S. D.","family":"Goldenberg","sequence":"first","affiliation":[{"name":"Centre for Clinical Infection and Diagnostics Research, Guy's &amp; St. Thomas' NHS Foundation Trust and King's College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Finn","sequence":"additional","affiliation":[{"name":"Guy's &amp; St. Thomas' NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sedudzi","sequence":"additional","affiliation":[{"name":"GSTS Pathology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A","family":"White","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, Guy's &amp; St. Thomas' NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Y. W.","family":"Tong","sequence":"additional","affiliation":[{"name":"Centre for Clinical Infection and Diagnostics Research, Guy's &amp; St. Thomas' NHS Foundation Trust and King's College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02398-09"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2010.009573"},{"key":"e_1_3_2_4_2","volume-title":"Sexually transmitted disease surveillance, 2010.","author":"Centers for Disease Control and Prevention","year":"2010","unstructured":"Centers for Disease Control and Prevention. 2010. Sexually transmitted disease surveillance, 2010. Centers for Disease Control and Prevention, Atlanta, GA."},{"key":"e_1_3_2_5_2","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","unstructured":"Centers for Disease Control and Prevention. 2010. Sexually transmitted diseases treatment guidelines, 2010. MMWR Morb. Mortal. Wkly. Rep. 59:1\u2013109.","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_6_2","article-title":"Use of nucleic acid amplification testing for the diagnosis of anorectal sexually transmitted infections","volume":"6","author":"Cosentino LA","year":"2012","unstructured":"CosentinoLA. 2012. Use of nucleic acid amplification testing for the diagnosis of anorectal sexually transmitted infections. J. Clin. Microbiol. 6:2005:8.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2011-050075"},{"key":"e_1_3_2_8_2","unstructured":"Health Protection Agency. 2010. Detection of Neisseria gonorrhoeae using molecular methods vol 1 p 1\u201315. Standards Unit Department for Evaluations Standards and Training Centre for Infections Health Protection Agency London United Kingdom."},{"key":"e_1_3_2_9_2","unstructured":"Health Protection Agency. 2012. Health protection report: HIV\/sexually transmitted infections in England 2011. http:\/\/hpa.org.uk\/hpr\/infections\/hiv_sti.htm. Health Protection Agency London United Kingdom."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02010.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-937-2_28"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181a2ad98"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02269-08"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e31817bdd7e"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008406"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1120-y"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01930-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01930-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T06:05:26Z","timestamp":1646460326000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01930-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1128\/JCM.01930-12"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01930-12","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717960021.793463181","asserted-by":"object"}]},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"2012-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}