{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:30:22Z","timestamp":1790386222705,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A total of 7,764 isolates from patients with invasive pneumococcal disease (IPD) were collected from 1992 to June 2006. Data on serotypes were available for 5,022 isolates (64.7% of all invasive isolates). Some 54.0% of the isolates originated from adults \u226516 years of age, and 46.0% were from children &lt;16 years of age. The leading serotypes were 14, 23F, 1, 6B, 7F, 3, and 4. The serotypes significantly more common in children were 14, 6B, 19F, and 18C, while among adults, serotypes 3 and 4 were predominant. Serotype 7F was statistically more prevalent among children &lt;4 months old than among the other age groups. Among children aged \u22654 months and &lt;1 year, serotype 19F occurred statistically more frequently; and among children aged \u22651 year to &lt;5 years, serotypes 14, 6B, and 18C were overrepresented. The serotypes predominantly affecting patients younger than the remaining collective of patients were 14, 6B, 19F, and 18C, while patients with IPD caused by serotypes 3, 4, and 9V were older than the collective, on average.<\/jats:p>","DOI":"10.1128\/jcm.01937-09","type":"journal-article","created":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T21:48:42Z","timestamp":1264628922000},"page":"1291-1296","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Association of Serotypes of\n                    <i>Streptococcus pneumoniae<\/i>\n                    with Age in Invasive Pneumococcal Disease"],"prefix":"10.1128","volume":"48","author":[{"given":"Matthias","family":"Imo\u0308hl","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and National Reference Center for Streptococci"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf Rene\u0301","family":"Reinert","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and National Reference Center for Streptococci"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ocklenburg","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, University Hospital (RWTH), Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and National Reference Center for Streptococci"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/3.2.183"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/423820"},{"key":"e_1_3_2_4_2","first-page":"90","volume":"2","year":"1998","unstructured":"de Cunto Brandileone, M. 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