{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:23:40Z","timestamp":1777944220674,"version":"3.51.4"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"PLATESA Comunidad de Madrid\/FEDER","award":["S2013\/ABI-2906"],"award-info":[{"award-number":["S2013\/ABI-2906"]}]},{"name":"PLATESA 2 Comunidad de Madrid\/FEDER","award":["S2018\/BAA-4370"],"award-info":[{"award-number":["S2018\/BAA-4370"]}]},{"name":"Centro para el Desarrollo Tecnol\u00f3gico Industrial","award":["IDI-20151125"],"award-info":[{"award-number":["IDI-20151125"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["BIO2017-83906-P"],"award-info":[{"award-number":["BIO2017-83906-P"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00210"],"award-info":[{"award-number":["PI18\/00210"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP14\/00121"],"award-info":[{"award-number":["CP14\/00121"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII19\/00001"],"award-info":[{"award-number":["CPII19\/00001"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00301"],"award-info":[{"award-number":["PI19\/00301"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PFIS FI19\/00119"],"award-info":[{"award-number":["PFIS FI19\/00119"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["MDM-2017-0737"],"award-info":[{"award-number":["MDM-2017-0737"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["SAF2014-52400-R"],"award-info":[{"award-number":["SAF2014-52400-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["BIO2016-79618R"],"award-info":[{"award-number":["BIO2016-79618R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["PID2019-104903RB-I00"],"award-info":[{"award-number":["PID2019-104903RB-I00"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["SAF2017-87846-R"],"award-info":[{"award-number":["SAF2017-87846-R"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["BFU2017-91384-EXP"],"award-info":[{"award-number":["BFU2017-91384-EXP"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PRE2018-083422"],"award-info":[{"award-number":["PRE2018-083422"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","award":["CB06\/04\/0086"],"award-info":[{"award-number":["CB06\/04\/0086"]}],"id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2020,11,18]]},"abstract":"<jats:p>Despite the high virological response rates achieved with current directly acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 2% to 5% of treated patients do not achieve a sustained viral response. The identification of amino acid substitutions associated with treatment failure requires analytical designs, such as subtype-specific ultradeep sequencing (UDS) methods, for HCV characterization and patient management. Using this procedure, we have identified six highly represented amino acid substitutions (HRSs) in NS5A and NS5B of HCV, which are not bona fide resistance-associated substitutions (RAS), from 220 patients who failed therapy.<\/jats:p>","DOI":"10.1128\/jcm.01985-20","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T10:28:35Z","timestamp":1601029715000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection"],"prefix":"10.1128","volume":"58","author":[{"given":"Mar\u00eda Eugenia","family":"Soria","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Garc\u00eda-Crespo","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"V\u00e1zquez-Sirvent","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Lobo-Vega","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Isabel","family":"de \u00c1vila","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Gallego","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damir","family":"Garc\u00eda-Cehic","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell","family":"Llorens-Revull","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Briones","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Centro de Astrobiolog\u00eda (CAB, CSIC-INTA), Torrej\u00f3n de Ardoz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Instituto de Parasitolog\u00eda y Biomedicina 'L\u00f3pez-Neyra' (CSIC), Parque Tecnol\u00f3gico Ciencias de la Salud, Armilla, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ferrer-Orta","sequence":"additional","affiliation":[{"name":"Structural Biology Department, Institut de Biolog\u00eda Molecular de Barcelona CSIC, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Verdaguer","sequence":"additional","affiliation":[{"name":"Structural Biology Department, Institut de Biolog\u00eda Molecular de Barcelona CSIC, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Gregori","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Roche Diagnostics, S.L., Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Rodr\u00edguez-Fr\u00edas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Biochemistry and Microbiology Departments, VHIR-HUVH, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Buti","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Ignacio","family":"Esteban","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Domingo","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Quer","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1618-1937","authenticated-orcid":false,"given":"Celia","family":"Perales","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"Liver Unit, Internal Medicine Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain"},{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.022"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.05023-11"},{"key":"e_1_3_3_4_2","first-page":"61","article-title":"Quasispecies on fitness landscapes","volume":"392","author":"Schuster P","year":"2016","unstructured":"Schuster P. 2016. Quasispecies on fitness landscapes. Curr Top Microbiol Immunol 392:61\u2013120.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-018-1282-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.10.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155869"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.021"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.104694"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13327"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.007"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12986"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2018.01.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0414-1"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/v11010003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S146595"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9849823"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-017-3640-6"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.043"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214854"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70033-1"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214853"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03127-14"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep19526"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit226"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu697"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00581-16"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.07.030"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01860-14"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3356-6"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt768"},{"key":"e_1_3_3_33_2","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Crespo C Soria ME Gallego I De \u00c1vila AI Mart\u00ednez-Gonz\u00e1lez B V\u00e1zquez-Sirvent L G\u00f3mez J Briones C Gregori J Quer J Perales C Domingo E. 2020. Dissimilar conservation pattern in hepatitis C virus mutant spectra consensus sequences and data banks. bioRxiv doi:10.1101\/2020.07.03.186171.","DOI":"10.1101\/2020.07.03.186171"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27375"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27934"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.011"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(96)66023-6"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2456"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503444200"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.592303"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005009"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27291-7"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216327"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1297925"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104278"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198642"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087773"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070666"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i11.2902"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.032"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.04024.x"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03052-14"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34254-5"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftz021"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02824-12"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052712599"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01985-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01985-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T05:39:54Z","timestamp":1646458794000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01985-20"}},"subtitle":[],"editor":[{"given":"Yi-Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,11,18]]}},"alternative-id":["10.1128\/JCM.01985-20"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01985-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.03.180240","asserted-by":"object"}]},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]},"assertion":[{"value":"2020-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01985-20"}}