{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:58:21Z","timestamp":1780444701598,"version":"3.54.1"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The most common complications of varicella are bacterial skin and soft tissue infections, generally due to\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            and group A beta-hemolytic streptococci. The aim of this study was to characterize the toxin and antibiotic resistance profiles of\n            <jats:italic>S. aureus<\/jats:italic>\n            isolates involved in varicella complications. Between 2002 and 2007, the French Reference Centre for Staphylococci collected 58\n            <jats:italic>S. aureus<\/jats:italic>\n            isolates involved in varicella superinfection. All the isolates were characterized by screening for 12 toxin genes,\n            <jats:italic>agr<\/jats:italic>\n            typing, and\n            <jats:italic>mecA<\/jats:italic>\n            gene detection; some isolates were also studied by\n            <jats:italic>spa<\/jats:italic>\n            typing, multilocus sequence typing (MLST), and resistance profiling. A major toxin gene was detected in 53% (31\/58) of the isolates (genes for exfoliative toxins A and B, 17.2%; Panton-Valentine leukocidin gene, 8.6%; toxic shock syndrome toxin 1 gene, 27.6%). Most clinical manifestations were directly compatible with the classical activity of these toxins. Nineteen isolates (33%) were resistant to methicillin, and 12 of these isolates belonged to an emerging\n            <jats:italic>agr-2<\/jats:italic>\n            , ST5 clone that harbors the toxic shock syndrome toxin 1 gene. These data should be considered in the management and treatment of patients with varicella complicated by\n            <jats:italic>S. aureus<\/jats:italic>\n            superinfection. Antibiotics that decrease toxin production, such as clindamycin, may provide benefit, and their efficacy against bacterial superinfections in children with varicella should be studied.\n          <\/jats:p>","DOI":"10.1128\/jcm.02018-09","type":"journal-article","created":{"date-parts":[[2010,3,20]],"date-time":"2010-03-20T01:38:49Z","timestamp":1269049129000},"page":"1696-1700","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Toxin Profiling of\n            <i>Staphylococcus aureus<\/i>\n            Strains Involved in Varicella Superinfection"],"prefix":"10.1128","volume":"48","author":[{"given":"Olivia","family":"Raulin","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u0301raldine","family":"Durand","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Gillet","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"},{"name":"Service d'Urgence et Re\u0301animation Pe\u0301diatriques, Hospices Civils de Lyon, Ho\u0302pital Femme Me\u0300re Enfant, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u0300le","family":"Bes","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Lina","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Vandenesch","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Floret","sequence":"additional","affiliation":[{"name":"Service d'Urgence et Re\u0301animation Pe\u0301diatriques, Hospices Civils de Lyon, Ho\u0302pital Femme Me\u0300re Enfant, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Etienne","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301ric","family":"Laurent","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lyon 1, Faculte\u0301 Laennec, and INSERM U851, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Lyon F-69008, and Hospices Civils de Lyon, Centre de Biologie Est, Bron F-69677, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.4.698"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/81385"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.8.1701"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1453-1457.2000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-1637-8"},{"key":"e_1_3_2_7_2","first-page":"30","volume":"8","year":"2005","unstructured":"Bonmarin, I., B. 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