{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:26:31Z","timestamp":1788323191916,"version":"build-2803163510"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            with a preexisting\n            <jats:italic>parC<\/jats:italic>\n            mutation is reported. Failure was due to the emergence of a\n            <jats:italic>gyrA<\/jats:italic>\n            mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isolates are discussed.\n          <\/jats:p>","DOI":"10.1128\/jcm.02066-07","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T01:59:05Z","timestamp":1203559145000},"page":"1558-1560","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with\n            <i>Streptococcus pneumoniae<\/i>\n            with a Preexisting\n            <i>parC<\/i>\n            Mutation"],"prefix":"10.1128","volume":"46","author":[{"given":"M.","family":"de Cueto","sequence":"first","affiliation":[{"name":"Department of Microbiology, University Hospital Virgen Macarena, Seville, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Rodri\u0301guez","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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