{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:02:16Z","timestamp":1787238136754,"version":"build-2736575974"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Extended-spectrum \u03b2-lactamases, plasmid-mediated AmpC \u03b2-lactamases (PABLs), and plasmid-mediated metallo-\u03b2-lactamases confer resistance to many \u03b2-lactams. In Japan, although several reports exist on the prevalence of extended-spectrum \u03b2-lactamases and metallo-\u03b2-lactamases, the prevalence and characteristics of PABLs remain unknown. To investigate the production of PABLs, a total of 22,869 strains of 4 enterobacterial species,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella oxytoca<\/jats:italic>\n                    , and\n                    <jats:italic>Proteus mirabilis<\/jats:italic>\n                    , were collected during six 6-month periods from 17 clinical laboratories in the Kinki region of Japan. PABLs were detected in 29 (0.13%) of 22,869 isolates by the 3-dimensional test, PCR analysis, and DNA sequencing analysis. PABL-positive isolates were detected among isolates from 13 laboratories. Seventeen of 13,995 (0.12%)\n                    <jats:italic>E. coli<\/jats:italic>\n                    isolates, 8 of 5,970 (0.13%)\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    isolates, 3 of 1,722 (0.17%)\n                    <jats:italic>K. oxytoca<\/jats:italic>\n                    isolates, and 1 of 1,182 (0.08%)\n                    <jats:italic>P. mirabilis<\/jats:italic>\n                    isolates were positive for PABLs. Of these 29 PABL-positive strains, 20 (69.0%), 6 (20.7%), 2 (6.9%), and 1 (3.4%) carried the genes for CMY-2, DHA-1, CMY-8, and MOX-1 PABLs, respectively. Pattern analysis of randomly amplified polymorphic DNA and pulsed-field gel electrophoretic analysis revealed that the prevalence of CMY-2-producing\n                    <jats:italic>E. coli<\/jats:italic>\n                    strains was not due to epidemic strains and that 3 DHA-1-producing\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    strains were identical, suggesting their clonal relatedness. In conclusion, the DHA-1 PABLs were predominantly present in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    strains, but CMY-2 PABLs were predominantly present in\n                    <jats:italic>E. coli<\/jats:italic>\n                    strains. The present findings will provide significant information to assist in preventing the emergence and further spread of PABL-producing bacteria.\n                  <\/jats:p>","DOI":"10.1128\/jcm.02111-09","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T23:10:02Z","timestamp":1278544202000},"page":"3267-3273","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Laboratory Surveillance for Prospective Plasmid-Mediated AmpC \u03b2-Lactamases in the Kinki Region of Japan"],"prefix":"10.1128","volume":"48","author":[{"given":"Katsutoshi","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Wakayama Rosai Hospital"},{"name":"Department of Biomedical Informatics, Osaka University Graduate School of 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Investigation, Kyoto University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Ono","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Japanese Red Cross Kyoto Daini Hospital, Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaaki","family":"Nishio","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Shiga Medical Center for Adults"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Sueyoshi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Social Insurance Shiga Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneyuki","family":"Kida","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Japanese Red Cross Otsu Hospital, Shiga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Kinki University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Toyokawa","sequence":"additional","affiliation":[{"name":"Laboratory for Clinical Investigation, Osaka University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Nishi","sequence":"additional","affiliation":[{"name":"Laboratory for Clinical Investigation, Osaka University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, The Research Foundation for Microbial Diseases of Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Osaka Police 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