{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:58:47Z","timestamp":1791273527070,"version":"4.1.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In 2005,\n                    <jats:italic>Candida nivariensis<\/jats:italic>\n                    , a yeast species genetically related to\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    , was described following its isolation from three patients in a single Spanish hospital. Between 2005 and 2006, 16 fungal isolates with phenotypic similarities to\n                    <jats:italic>C. nivariensis<\/jats:italic>\n                    were submitted to the United Kingdom Mycology Reference Laboratory for identification. The strains originated from various clinical specimens, including deep, usually sterile sites, from patients at 12 different hospitals in the United Kingdom. PCR amplification and sequencing of the D1D2 and internal transcribed spacer 1 (ITS1) regions of the nuclear ribosomal gene cassette confirmed that these isolates from the United Kingdom are genetically identical to\n                    <jats:italic>C. nivariensis<\/jats:italic>\n                    . Biochemically,\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    and\n                    <jats:italic>C. nivariensis<\/jats:italic>\n                    are distinguished by their differential abilities to assimilate trehalose. However, in contrast to the original published findings, we found that\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    isolates, but not\n                    <jats:italic>C. nivariensis<\/jats:italic>\n                    isolates, are capable of assimilating this substrate. Antifungal susceptibility tests revealed that\n                    <jats:italic>C. nivariensis<\/jats:italic>\n                    isolates are less susceptible than\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    isolates to itraconazole, fluconazole, and voriconazole and to have significantly higher flucytosine MICs than\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    strains. Finally,\n                    <jats:italic>C. nivariensis<\/jats:italic>\n                    could be rapidly distinguished from the other common pathogenic fungus species by pyrosequencing of the ITS2 region. In the light of these data, we believe that\n                    <jats:italic>C. nivariensis<\/jats:italic>\n                    should be regarded as a clinically important emerging pathogenic fungus.\n                  <\/jats:p>","DOI":"10.1128\/jcm.02116-07","type":"journal-article","created":{"date-parts":[[2008,1,16]],"date-time":"2008-01-16T20:44:57Z","timestamp":1200516297000},"page":"933-938","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":119,"title":["<i>Candida nivariensis<\/i>\n                    , an Emerging Pathogenic Fungus with Multidrug Resistance to Antifungal Agents"],"prefix":"10.1128","volume":"46","author":[{"given":"Andrew M.","family":"Borman","sequence":"first","affiliation":[{"name":"Mycology Reference Laboratory, Health Protection Agency, Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Petch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Bristol, Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Linton","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, Health Protection Agency, Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, Health Protection Agency, Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Bridge","sequence":"additional","affiliation":[{"name":"British Antarctic Survey, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, Health Protection Agency, Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.4107-4111.2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.12.6194-6196.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_5_2","unstructured":"Yeasts: characteristics and identification 2000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780600564613"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.3.821-823.1999"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.9.807"},{"key":"e_1_3_2_9_2","first-page":"154","volume":"5","year":"1989","unstructured":"Felsenstein, J. 1989. 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