{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:24:44Z","timestamp":1784330684485,"version":"3.55.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The effective management of women with human papillomavirus (HPV)-positive, cytology-negative results is critical to the introduction of HPV testing into cervical screening. HPV typing has been recommended for colposcopy triage, but it is not clear which combinations of high-risk HPV types provide clinically useful information. This study included 18,810 women with Hybrid Capture 2 (HC2)-positive, cytology-negative results and who were age \u226530 years from Kaiser Permanente Northern California. The median follow-up was 475 days (interquartile range [IQR], 0 to 1,077 days; maximum, 2,217 days). The baseline specimens from 482 cases of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) and 3,517 random HC2-positive noncases were genotyped using 2 PCR-based methods. Using the case-control sampling fractions, the 3-year cumulative risks of CIN3+ were calculated for each individual high-risk HPV type. The 3-year cumulative risk of CIN3+ among all women with HC2-positive, cytology-negative results was 4.6%. HPV16 status conferred the greatest type-specific risk stratification; women with HC2-positive\/HPV16-positive results had a 10.6% risk of CIN3+, while women with HC-2 positive\/HPV16-negative results had a much lower risk of 2.4%. The next most informative HPV types and their risks in HPV-positive women were HPV33 (5.9%) and HPV18 (5.9%). With regard to the etiologic fraction, 20 of 71 cases of cervical adenocarcinoma\n            <jats:italic>in situ<\/jats:italic>\n            (AIS) and adenocarcinoma in the cohort were positive for HPV18. HPV16 genotyping provides risk stratification useful for guiding clinical management; the risk among HPV16-positive women clearly exceeds the U.S. consensus risk threshold for immediate colposcopy referral. HPV18 is of particular interest because of its association with difficult-to-detect glandular lesions. There is a less clear clinical value of distinguishing the other high-risk HPV types.\n          <\/jats:p>","DOI":"10.1128\/jcm.02116-14","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T02:07:39Z","timestamp":1414030059000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":93,"title":["A Study of Genotyping for Management of Human Papillomavirus-Positive, Cytology-Negative Cervical Screening Results"],"prefix":"10.1128","volume":"53","author":[{"given":"M.","family":"Schiffman","sequence":"first","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Burk","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Roche Molecular Systems, Pleasanton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Raine-Bennett","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Katki","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Gage","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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