{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:08:30Z","timestamp":1722931710118},"reference-count":30,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We studied 358\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            strains isolated from bloodstream infections (BSI) observed during an epidemiological study covering 2,007,681 days of hospitalization in 32 healthcare institutions (HCIs) between 2004 and 2006. The strains were tested for antibiotic susceptibility and characterized genetically. The incidence of\n            <jats:italic>S. aureus<\/jats:italic>\n            BSI declined regularly through 2004 and 2005 and then significantly increased in 2006 (+80%). This was largely due to an increase in BSI involving methicillin-sensitive\n            <jats:italic>S. aureus<\/jats:italic>\n            (MSSA) strains and nonmultiresistant methicillin-resistant\n            <jats:italic>S. aureus<\/jats:italic>\n            (NORSA) strains. Ninety-six percent of the NORSA strains were resistant only to methicillin and fluoroquinolones. Most of the MSSA strains belonged to a small number of pulsed-field gel electrophoresis (PFGE) divisions and were associated with epidemic phenomena in HCIs. The NORSA strains also clustered into a limited number of PFGE divisions but could not be related to any local outbreak in HCIs. In 2006, there was a significant increase in the incidence of BSI associated with\n            <jats:italic>tst<\/jats:italic>\n            gene-positive MSSA strains (+275%) and the first three BSI associated with\n            <jats:italic>tst<\/jats:italic>\n            gene-positive MRSA were observed. PFGE data revealed a limited heterogeneity among the\n            <jats:italic>tst<\/jats:italic>\n            gene-positive strains without any outbreak in the HCIs. Our study underlines the need for infection control teams to focus efforts on preventing both MRSA and MSSA BSI. As recently demonstrated in vitro, fluoroquinolones may enhance horizontal transfer of virulence and antibiotic resistance genes. These antibiotics are widely used in France, so our findings raise the issue of whether their use has contributed to the acquisition of\n            <jats:italic>mecA<\/jats:italic>\n            and\n            <jats:italic>tst<\/jats:italic>\n            genes by\n            <jats:italic>S. aureus<\/jats:italic>\n            strains.\n          <\/jats:p>","DOI":"10.1128\/jcm.02178-06","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T05:51:58Z","timestamp":1169704318000},"page":"851-857","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["<i>Staphylococcus aureus<\/i>\n            Strains Isolated from Bloodstream Infections Changed Significantly in 2006"],"prefix":"10.1128","volume":"45","author":[{"given":"Nathalie","family":"van der Mee-Marquet","sequence":"first","affiliation":[{"name":"EA 3854, IFR 136, UFR Me\u0301decine Universite\u0301 Franc\u0327ois-Rabelais, 2 bis boulevard Tonnele\u0301, 37032 Tours Cedex, France"},{"name":"Service de Bacte\u0301riologie et d'Hygie\u0300ne, Ho\u0302pital Trousseau, Centre Hospitalier Universitaire, F37044 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Epinette","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie et d'Hygie\u0300ne, Ho\u0302pital Trousseau, Centre Hospitalier Universitaire, F37044 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Loyau","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie et d'Hygie\u0300ne, Ho\u0302pital Trousseau, Centre Hospitalier Universitaire, F37044 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Arnault","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie et d'Hygie\u0300ne, Ho\u0302pital Trousseau, Centre Hospitalier Universitaire, F37044 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Domelier","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie et d'Hygie\u0300ne, Ho\u0302pital Trousseau, Centre Hospitalier Universitaire, F37044 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Losfelt","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie et d'Hygie\u0300ne, Ho\u0302pital Trousseau, Centre Hospitalier Universitaire, F37044 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Girard","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie et d'Hygie\u0300ne, Ho\u0302pital Trousseau, Centre Hospitalier Universitaire, F37044 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Quentin","sequence":"additional","affiliation":[{"name":"EA 3854, IFR 136, UFR Me\u0301decine Universite\u0301 Franc\u0327ois-Rabelais, 2 bis boulevard Tonnele\u0301, 37032 Tours Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"and the Bloodstream Infection Study Group of the Relais d'Hygie\u0300ne du Centre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540500447150"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02241"},{"key":"e_1_3_2_4_2","unstructured":"Centers for Disease Control and Prevention. 2001. 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