{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:06:45Z","timestamp":1769684805365,"version":"3.49.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We used large sequence polymorphisms to determine the genotypes of 397 isolates of\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            from human immunodeficiency virus-uninfected Vietnamese adults with pulmonary (\n            <jats:italic>n<\/jats:italic>\n            = 235) or meningeal (\n            <jats:italic>n<\/jats:italic>\n            = 162) tuberculosis. We compared the pretreatment radiographic appearances of pulmonary tuberculosis and the presentation, response to treatment, and outcome of tuberculous meningitis between the genotypes. Multivariate analysis identified variables independently associated with genotype and outcome. A higher proportion of adults with pulmonary tuberculosis caused by the Euro-American genotype had consolidation on chest X-ray than was the case with disease caused by other genotypes (\n            <jats:italic>P<\/jats:italic>\n            = 0.006). Multivariate analysis revealed that meningitis caused by the East Asian\/Beijing genotype was independently associated with a shorter duration of illness before presentation and fewer cerebrospinal fluid (CSF) leukocytes. Older age, fewer CSF leukocytes, and the presence of hemiplegia (but not strain lineage) were independently associated with death or severe disability, although the East Asian\/Beijing genotype was strongly associated with drug-resistant tuberculosis. The genotype of\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            influenced the presenting features of pulmonary and meningeal tuberculosis. The association between the East Asian\/Beijing lineage and disease progression and CSF leukocyte count suggests the lineage may alter the presentation of meningitis by influencing the intracerebral inflammatory response. In addition, increased drug resistance among bacteria of the East Asian\/Beijing lineage might influence the response to treatment. This study suggests the genetic diversity of\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            has important clinical consequences.\n          <\/jats:p>","DOI":"10.1128\/jcm.02180-07","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T01:59:05Z","timestamp":1203559145000},"page":"1363-1368","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":128,"title":["Relationship between\n            <i>Mycobacterium tuberculosis<\/i>\n            Genotype and the Clinical Phenotype of Pulmonary and Meningeal Tuberculosis"],"prefix":"10.1128","volume":"46","author":[{"given":"Guy","family":"Thwaites","sequence":"first","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom"},{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxine","family":"Caws","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"},{"name":"Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Thi Hong","family":"Chau","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"},{"name":"The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"D'Sa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Brighton, and Sussex University Hospitals, Eastern Road, Brighton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Ngoc","family":"Lan","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, Huong Vuong, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Nguyet Thu","family":"Huyen","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, Huong Vuong, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Gagneux","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, 1441 N. 34th Street, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Thi Hoang","family":"Anh","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, Huong Vuong, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dau Quang","family":"Tho","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estee","family":"Torok","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"},{"name":"Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Quynh","family":"Nhu","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Hong","family":"Duyen","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Minh","family":"Duy","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Richenberg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Brighton, and Sussex University Hospitals, Eastern Road, Brighton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Simmons","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"},{"name":"Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Tinh","family":"Hien","sequence":"additional","affiliation":[{"name":"The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Farrar","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam"},{"name":"Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021964"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652407780598593"},{"key":"e_1_3_2_4_2","first-page":"313","volume":"25","year":"1961","unstructured":"Bhatia, A. L., A. Csillag, D. A. Mitchison, J. B. Selkon, P. R. Somasundaram, and T. V. Subbaiah. 1961. The virulence in the guinea-pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis. 2. Comparison with virulence of tubercle bacilli from British patients. Bull. W. H. O.25:313-322.","journal-title":"Bull. W. H. O."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2003.10.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01181-06"},{"key":"e_1_3_2_7_2","unstructured":"Tuberculous bacteriology: organisation and practice 1997"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206538200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02551.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2726"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511240103"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70108-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/507907"},{"key":"e_1_3_2_14_2","first-page":"261","volume":"3","year":"1999","unstructured":"Kalita, J., and U. K. Misra. 1999. Outcome of tuberculous meningitis at 6 and 12 months: a multiple regression analysis. Int. J. Tuberc. Lung Dis.3:261-265.","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01459-06"},{"key":"e_1_3_2_16_2","first-page":"646","volume":"9","year":"2005","unstructured":"Kubica, T., R. Agzamova, A. Wright, M. A. Aziz, G. Rakishev, V. Bismilda, E. Richter, S. Rusch-Gerdes, and S. Niemann. 2005. The Beijing genotype is a major cause of drug-resistant tuberculosis in Kazakhstan. Int. J. Tuberc. Lung Dis.9:646-653.","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)01310-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091096998"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000247044.05140.c7"},{"key":"e_1_3_2_20_2","first-page":"285","volume":"25","year":"1961","unstructured":"Mitchison, D. A., A. L. Bhatia, S. Radhakrishna, J. B. Selkon, T. V. Subbaiah, and J. G. Wallace. 1961. The virulence in the guinea-pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis. I. Homogeneity of the investigation and a critique of the virulence test. Bull. W. H. O.25:285-312.","journal-title":"Bull. W. H. O."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-3879(60)80019-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15496-2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604283103"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5779-5781.2005"},{"key":"e_1_3_2_25_2","first-page":"323","volume":"25","year":"1961","unstructured":"Ramakrishnan, C. V., A. L. Bhatia, W. Fox, D. A. Mitchison, S. Radhakrishna, J. B. Selkon, J. B. Selkon, T. V. Subbaiah, S. Velu, and J. G. Wallace. 1961. The virulence in the guinea-pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis. 3. Virulence related to pretreatment status of disease and to response to chemotherapy. Bull. W. H. O.25:323-338.","journal-title":"Bull. W. H. O."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02837"},{"key":"e_1_3_2_27_2","first-page":"5","volume":"52","year":"1933","unstructured":"Rich, A. R., and H. A. McCordock. 1933. The pathogenesis of tuberculous meningitis. Bull. John Hopkins Hosp.52:5-37.","journal-title":"Bull. John Hopkins Hosp."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.2007"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364405"},{"key":"e_1_3_2_30_2","first-page":"865","volume":"6","year":"2002","unstructured":"Thwaites, G. E., T. T. Chau, M. Caws, N. H. Phu, L. V. Chuong, D. X. Sinh, F. Drobniewski, N. J. White, C. M. Parry, and J. J. Farrar. 2002. Isoniazid resistance, mycobacterial genotype and outcome in Vietnamese adults with tuberculous meningitis. Int. J. Tuberc. Lung Dis.6:865-871.","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/430616"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040573"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/378642"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/430614"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.7.3185-3191.2005"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803053381001"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0705.017518"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1147OC"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02180-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02180-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T06:26:53Z","timestamp":1646461613000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.02180-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1128\/JCM.02180-07"],"URL":"https:\/\/doi.org\/10.1128\/jcm.02180-07","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"2007-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}