{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:14:36Z","timestamp":1791044076551,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Community respiratory viruses (CRVs) are commonly associated with seasonal infections. They have been associated with higher morbidity and mortality among children, elderly individuals, and immunosuppressed patients. In April 2009, the circulation of a new influenza A virus (FLUA H1N1v) was responsible for the first influenza pandemic of this century. We report the clinical and epidemiological profiles of inpatients infected with CRVs or with FLUA H1N1v at a tertiary care hospital in southern Brazil. In addition, we used these profiles to evaluate survivor and nonsurvivor patients infected with FLUA H1N1v. Multiplex reverse transcription-PCR (RT-PCR) and real time RT-PCR were used to detect viruses in inpatients with respiratory infections. Record data from all patients were reviewed. A total of 171 patients were examined over a period of 16 weeks. Of these, 39% were positive for FLUA H1N1v, 36% were positive for CRVs, and 25% were negative. For the FLUA H1N1v- and CRV-infected patients, epidemiological data regarding median age (30 and 1.5 years), myalgia (44% and 13%), need for mechanical ventilation (44% and 9%), and mortality (35% and 9%) were statistically different. In a multivariate analysis comparing survivor and nonsurvivor patients infected with influenza A virus H1N1, median age and creatine phosphokinase levels were significantly associated with a severe outcome. Seasonal respiratory infections are a continuing concern. Our results highlight the importance of studies on the prevalence and severity of these infections and that investments in programs of clinical and laboratory monitoring are essential to detect the appearance of new infective agents.<\/jats:p>","DOI":"10.1128\/jcm.02205-10","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T03:27:24Z","timestamp":1295494044000},"page":"1287-1293","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Laboratory Diagnosis, Epidemiology, and Clinical Outcomes of Pandemic Influenza A and Community Respiratory Viral Infections in Southern Brazil"],"prefix":"10.1128","volume":"49","author":[{"given":"Sonia M.","family":"Raboni","sequence":"first","affiliation":[{"name":"Carlos Chagas Institute, Fiocruz\/Paran\u00e1, Curitiba, Paran\u00e1, Brazil"},{"name":"Department of Infectious Diseases, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Stella","sequence":"additional","affiliation":[{"name":"Carlos Chagas Institute, Fiocruz\/Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina R.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o B.","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Moreira","sequence":"additional","affiliation":[{"name":"Epidemiology Service, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Epidemiology Service, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meri B.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luine R.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio M.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Debur","sequence":"additional","affiliation":[{"name":"Public Health Laboratory, Secretaria Estadual de Sa\u00fade do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Hipolito","family":"Carraro","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Universidade Federal do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia N.","family":"Duarte dos Santos","sequence":"additional","affiliation":[{"name":"Carlos Chagas Institute, Fiocruz\/Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504666102"},{"key":"e_1_3_2_3_2","unstructured":"Brazilian Ministry of Health. 2010. 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