{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:40:19Z","timestamp":1790991619083,"version":"4.1.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:named-content content-type=\"genus-species\">Candida haemulonii<\/jats:named-content>\n            species complex is currently known as\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            groups I and II. Here we describe\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            group II as a new species,\n            <jats:named-content content-type=\"genus-species\">Candida duobushaemulonii<\/jats:named-content>\n            sp. nov., and\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            var.\n            <jats:named-content content-type=\"genus-species\">vulnera<\/jats:named-content>\n            as new a variety of\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            group I using phenotypic and molecular methods. These taxa and other relatives of\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            (i.e.,\n            <jats:named-content content-type=\"genus-species\">Candida auris<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Candida pseudohaemulonii<\/jats:named-content>\n            ) cannot be differentiated by the commercial methods now used for yeast identification. Four isolates (\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            var.\n            <jats:named-content content-type=\"genus-species\">vulnera<\/jats:named-content>\n            ) differed from the other isolates of\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            in the sequence of the internal transcribed spacer (ITS) regions of the nuclear rRNA gene operon. The new species and the new variety have a multiresistant antifungal profile, which includes high MICs of amphotericin B (geometric mean MIC, 1.18 mg\/liter for\n            <jats:named-content content-type=\"genus-species\">C. haemulonii<\/jats:named-content>\n            var.\n            <jats:named-content content-type=\"genus-species\">vulnera<\/jats:named-content>\n            and 2 mg\/liter for\n            <jats:named-content content-type=\"genus-species\">C. duobushaemulonii<\/jats:named-content>\n            sp. nov) and cross-resistance to azole compounds. Identification of these species should be based on molecular methods, such as sequence analysis of ITS regions and matrix-assisted laser desorption ionization\u2013time of flight mass spectrometry.\n          <\/jats:p>","DOI":"10.1128\/jcm.02248-12","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T05:11:49Z","timestamp":1346908309000},"page":"3641-3651","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":220,"title":["Reclassification of the Candida haemulonii Complex as Candida haemulonii (C. haemulonii Group I), C. duobushaemulonii sp. nov. (C. haemulonii Group II), and C. haemulonii var. vulnera var. nov.: Three Multiresistant Human Pathogenic Yeasts"],"prefix":"10.1128","volume":"50","author":[{"given":"E.","family":"Cendejas-Bueno","sequence":"first","affiliation":[{"name":"Servicio de Micolog\u00eda, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kolecka","sequence":"additional","affiliation":[{"name":"CBS-KNAW Fungal Biodiversity Centre, Yeast and Basidiomycete Research, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alastruey-Izquierdo","sequence":"additional","affiliation":[{"name":"Servicio de Micolog\u00eda, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Theelen","sequence":"additional","affiliation":[{"name":"CBS-KNAW Fungal Biodiversity Centre, Yeast and Basidiomycete Research, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Groenewald","sequence":"additional","affiliation":[{"name":"CBS-KNAW Fungal Biodiversity Centre, Yeast and Basidiomycete Research, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kostrzewa","sequence":"additional","affiliation":[{"name":"Bioanalytical Development, Bruker Daltonik GmbH, Bremen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cuenca-Estrella","sequence":"additional","affiliation":[{"name":"Servicio de Micolog\u00eda, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"G\u00f3mez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Servicio de Micolog\u00eda, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Boekhout","sequence":"additional","affiliation":[{"name":"CBS-KNAW Fungal Biodiversity Centre, Yeast and Basidiomycete Research, Utrecht, The Netherlands"},{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.4107-4111.2005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2001.tb00037.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.4.1357-1362.2003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00336-10"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.64076-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03471.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(08)70016-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.917-921.2006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1469-0691.2003.00592.x","article-title":"Multicenter evaluation of the reproducibility of the proposed antifungal susceptibility testing method for fermentative yeasts of the Antifungal Susceptibility Testing Subcommittee of the European Committee on Antimicrobial Susceptibility Testing (AFST-EUCAST)","volume":"9","author":"Cuenca-Estrella M","year":"2003","unstructured":"Cuenca-EstrellaM. 2003. 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