{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:15:48Z","timestamp":1787501748793,"version":"build-2736575974"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100010798","name":"Sunway University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010798","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:named-content content-type=\"genus-species\">Acanthamoeba<\/jats:named-content>\n                    spp. and\n                    <jats:named-content content-type=\"genus-species\">Balamuthia mandrillaris<\/jats:named-content>\n                    are causative agents of granulomatous amoebic encephalitis (GAE), while\n                    <jats:named-content content-type=\"genus-species\">Naegleria fowleri<\/jats:named-content>\n                    causes primary amoebic meningoencephalitis (PAM). PAM is an acute infection that lasts a few days, while GAE is a chronic to subacute infection that can last up to several months. Here, we present a literature review of 86 case reports from 1968 to 2016, in order to explore the affinity of these amoebae for particular sites of the brain, diagnostic modalities, treatment options, and disease outcomes in a comparative manner.\n                  <\/jats:p>","DOI":"10.1128\/jcm.02300-16","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T20:40:22Z","timestamp":1492029622000},"page":"1989-1997","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":99,"title":["Brain-Eating Amoebae: Predilection Sites in the Brain and Disease Outcome"],"prefix":"10.1128","volume":"55","author":[{"given":"Timothy Yu Yee","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, School of Science and Technology, Sunway University, Bandar Sunway, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed Ahmed","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Science and Technology, Sunway University, Bandar Sunway, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqaiyyah","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Science and Technology, Sunway University, Bandar Sunway, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00232.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2006.00023.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00056-07"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.52.1.114-133.1988"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.07.023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4303\/jnp\/N100802"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003017"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2014.07.011"},{"key":"e_1_3_3_10_2","first-page":"930","article-title":"Neuroimaging findings in rare amoebic infections of the central nervous system","volume":"16","author":"Schumacher DJ","year":"1995","unstructured":"Schumacher DJ Tien RD Lane K . 1995. Neuroimaging findings in rare amoebic infections of the central nervous system. AJNR Am J Neuroradiol16:930\u2013935.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/49.1.84"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.2.324"},{"key":"e_1_3_3_13_2","first-page":"1217","article-title":"Amoebic meningoencephalitis: spectrum of imaging findings","volume":"27","author":"Singh P","year":"2006","unstructured":"Singh P Kochhar R Vashishta RK Khandelwal N Prabhakar S Mohindra S Singhi P . 2006. Amoebic meningoencephalitis: spectrum of imaging findings. 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