{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:17:15Z","timestamp":1790864235113,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Over a 2-year period (2003 to 2005) patients with community-associated methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (CA-MRSA) and community-acquired methicillin-susceptible\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (CA-MSSA) infections were prospectively identified. Patients infected with CA-MRSA (\n            <jats:italic>n<\/jats:italic>\n            = 102 patients) and CA-MSSA (\n            <jats:italic>n<\/jats:italic>\n            = 102 patients) had median ages of 46 and 53 years, respectively; the most common sites of infection in the two groups were skin\/soft tissue (80 and 93%, respectively), respiratory tract (13 and 6%, respectively), and blood (4 and 1%, respectively). Fourteen percent of patients with CA-MRSA infections and 3% of patients with CA-MSSA infections had household contacts with similar infections (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). Among the CA-MRSA isolates, the pulsed-field gel electrophoresis (PFGE) groups detected were USA300 (49%) and USA100 (13%), with 27 PFGE groups overall; 71% of the isolates were staphylococcal chromosome cassette\n            <jats:italic>mec<\/jats:italic>\n            (SCC\n            <jats:italic>mec<\/jats:italic>\n            ) type IV, 29% were SCC\n            <jats:italic>mec<\/jats:italic>\n            type II, and 54% had the Panton-Valentine leucocidin (PVL) gene. Among the CA-MSSA isolates there were 33 PFGE groups, with isolates of the USA200 group comprising 11%, isolates of the USA600 group comprising 11%, isolates of the USA100 group comprising 10%, and isolates of the PVL type comprising 10%. Forty-six and 18% of the patients infected with CA-MRSA and CA-MSSA, respectively, were hospitalized (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Fifty percent of the patients received antibiotic therapy alone, 5% received surgery alone, 30% received antibiotics and surgery, 3% received other therapy, and 12% received no treatment. The median durations of antibiotic therapy were 12 and 10 days in the CA-MRSA- and CA-MSSA-infected patients, respectively; 48 and 56% of the patients in the two groups received adequate antimicrobial therapy, respectively (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). The clinical success rates of the initial therapy in the two groups were 61 and 84%, respectively (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001); recurrences were more common in the CA-MRSA group (recurrences were detected in 18 and 6% of the patients in the two groups, respectively [\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001]). CA-MRSA was an independent predictor of clinical failure in multivariate analysis (odds ratio, 3.4; 95% confidence interval, 1.7 to 6.9). In the community setting, the molecular characteristics of the\n            <jats:italic>S. aureus<\/jats:italic>\n            strains were heterogeneous. CA-MRSA infections were associated with a more adverse impact on outcome than CA-MSSA infections.\n          <\/jats:p>","DOI":"10.1128\/jcm.02311-06","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T00:49:32Z","timestamp":1175129372000},"page":"1705-1711","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":148,"title":["Epidemiology and Outcomes of Community-Associated Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>\n            Infection"],"prefix":"10.1128","volume":"45","author":[{"given":"S. L.","family":"Davis","sequence":"first","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"},{"name":"Eugene Applebaum College of Pharmacy and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Perri","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Donabedian","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Manierski","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Singh","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Vager","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Z.","family":"Haque","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Speirs","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. R.","family":"Muder","sequence":"additional","affiliation":[{"name":"Pittsburgh Veterans Administration Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Robinson-Dunn","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Chicago Rush University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Zervos","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, Michigan"},{"name":"School of Medicine, Wayne State University, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"384","year":"2003","unstructured":"Bannerman, T. L. 2003. Staphylococcus, Micrococcus, and other catalase-positive cocci that grow aerobically, p. 384-404. In P. R. Murray, E. J. Baron, J. H. Jorgensen, M. A. Pfaller, and R. H. Yolken (ed.), Manual of clinical microbiology, 8th ed. ASM Press, Washington, DC.","journal-title":"Manual of clinical microbiology"},{"key":"e_1_3_2_3_2","first-page":"1123","volume":"282","year":"1999","unstructured":"Centers for Disease Control and Prevention. 1999. Four pediatric deaths from community-acquired methicillin-resistant Staphylococus aureus-Minnesota and North Dakota, 1997-1999. JAMA282:1123-1125.","journal-title":"JAMA"},{"key":"e_1_3_2_4_2","first-page":"992","volume":"52","year":"2003","unstructured":"Centers for Disease Control and Prevention. 2003. Methicillin-resistant Staphylococus aureus infections in correctional facilities\u2014Georgia, California, and Texas, 2001-2003. Morb. Mortal. Wkly. Rep.52:992-996.","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_5_2","first-page":"793","volume":"52","year":"2003","unstructured":"Centers for Disease Control and Prevention. 2003. Methicillin-resistant Staphylococus aureus infections among competitive sports participants\u2014Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000-2003. Morb. Mortal. Wkly. Rep.52:793-795.","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_6_2","first-page":"767","volume":"53","year":"2004","unstructured":"Centers for Disease Control and Prevention. 2004. 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