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The annual evolution rate of CVA16 was estimated as approximately 0.91 \u00d7 10<jats:sup>\u22122<\/jats:sup>substitutions per synonymous nucleotide\/year and is slightly lower than that of HEV71.<\/jats:p>","DOI":"10.1128\/jcm.02338-09","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T05:15:05Z","timestamp":1261026905000},"page":"619-622","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":131,"title":["Molecular Evidence of Persistent Epidemic and Evolution of Subgenotype B1 Coxsackievirus A16-Associated Hand, Foot, and Mouth Disease in China"],"prefix":"10.1128","volume":"48","author":[{"given":"Yong","family":"Zhang","sequence":"first","affiliation":[{"name":"WHO WPRO Regional Polio Reference Laboratory and State Key Laboratory for Molecular Virology &amp; Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 27, Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Wang","sequence":"additional","affiliation":[{"name":"WHO WPRO Regional Polio Reference Laboratory and State Key Laboratory for Molecular Virology &amp; 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